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HelpTest ID 60921 Ki-67 (MIB-1), Immunostain Without Interpretation
Useful For
A marker of proliferation in neoplasms
Method Name
Immunohistochemistry
Reporting Name
Ki-67 (MIB-1) IHC, no interpSpecimen Type
TissueSpecimen Type: Tissue
Container/Tube: Immunostain Technical Only Envelope (Supply T693)
Preferred: Formalin-fixed, paraffin-embedded (FFPE) tissue block
Acceptable: 2 unstained positively charged glass slides (25 x 75 x 1 mm) per test ordered; sections 4 microns thick
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Tissue | Ambient (preferred) | |
| Refrigerated | ||
Clinical Information
Ki-67 (antibody clone MIB-1), is a nuclear protein playing a pivotal role in maintaining cell proliferation. Ki-67 is present in all non-G0 phases of the cell cycle. Beginning in the mid-G1, the level increases through S and G2 to reach a peak in M phase. In the end of M phase, it is rapidly catabolized. Ki-67 has been employed as a marker of proliferation and hence prognosis in neoplasms of many types, such as malignant lymphomas, prostatic and breast adenocarcinomas, astrocytic neoplasms, and soft tissue neoplasms.
Cautions
No significant cautionary statements
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
88342-TC, primary
88341-TC, if additional IHC