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HelpTest ID 60939 Napsin A, Immunostain Without Interpretation
Useful For
An aid in the identification of primary lung adenocarcinoma
Method Name
Immunohistochemistry
Reporting Name
Napsin A IHC, no interpSpecimen Type
TissueSpecimen Type: Tissue
Container/Tube: Immunostain Technical Only Envelope (Supply T693)
Preferred: Formalin-fixed, paraffin-embedded (FFPE) tissue block
Acceptable: 2 unstained positively charged glass slides (25 x 75 x 1 mm) per test ordered; sections 4 microns thick
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Tissue | Ambient (preferred) | |
| Refrigerated | ||
Clinical Information
Napsin A is an aspartic proteinase involved in the proteolytic processing of surfactant precursors in the normal alveolar epithelium. In normal tissues, Napsin A is expressed in the cytoplasm of alveolar macrophages, type II pneumocytes, pancreatic ducts and acini, and in renal tubules. Napsin A has clinical utility for the identification of primary lung adenocarcinomas. Napsin A is also positive in a subset of thyroid and renal cell carcinomas (especially papillary types).
Cautions
No significant cautionary statements
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
88342-TC, primary
88341-TC, if additional IHC