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HelpTest ID 60943 p16 (INK4a/CDKN2A), Immunostain Without Interpretation
Useful For
As an aid in the identification of human papilloma virus infection
Method Name
Immunohistochemistry
Reporting Name
p16 (INK4a/CDKN2A) IHC, no interpSpecimen Type
TissueSpecimen Type: Tissue
Container/Tube: Immunostain Technical Only Envelope (Supply T693)
Preferred: Formalin-fixed, paraffin-embedded (FFPE) tissue block
Acceptable: 2 unstained positively charged glass slides (25 x 75 x 1 mm) per test ordered; sections 4 microns thick
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Tissue | Ambient (preferred) | |
| Refrigerated | ||
Clinical Information
p16 (INK4a/CDKN2A) is a cell cycle regulatory protein that is over expressed in cervical dysplasia related to human papilloma virus (HPV) infection. Nuclear and cytoplasmic staining is seen in dysplastic squamous cervical epithelial cells infected with HPV, but not in normal cells. A subset of pancreatic islet cells and dendritic cells show expression of p16, and can serve as positive control.
Cautions
No significant cautionary statements
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
88342-TC, primary
88341-TC, if additional IHC