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HelpTest ID ATITH Isoagglutinin Titer, Anti-A, Serum
Useful For
Evaluation of individuals with possible hypogammaglobulinemia
Investigation of suspected roundworm infections
Method Name
Hemagglutination
Reporting Name
Isoagglutinin Titer, Anti-ASpecimen Type
Serum RedSpecimen must arrive within 10 days of draw.
Container/Tube: Red top
Specimen Volume: 2.5 mL
Additional Information:
1. Include patient's blood type and age.
2. If test BTITH / Isoagglutinin Titer, Anti-B, Serum is also requested for Type O patients, 1 tube containing 2.5 mL of serum is acceptable for both tests.
Forms: If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/benign-hematology-test-request-form.pdf)
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Ambient (preferred) | 4 days |
| Frozen | 10 days | |
| Refrigerated | 10 days |
Clinical Information
Isoagglutinins are antibodies produced by an individual that cause agglutination of RBCs in other individuals. People possess isoagglutinins directed toward the A or B antigen absent from their own RBCs. For example, type B or O individuals will usually possess anti-A. The anti-A is formed in response to exposure to A-like antigenic structures found in ubiquitous non-red cell biologic entities (eg, bacteria).
Isoagglutinins present in the newborn are passively acquired from maternal circulation. Such passively acquired isoagglutinins will gradually disappear, and the infant will begin to produce isoagglutinins at 3 to 6 months of age.
Isoagglutinin production may vary in patients with certain pathologic conditions. Decreased levels of isoagglutinins may be seen in patients with acquired and congenital hypogammaglobulinemia and agammaglobulinemia. Some individuals with roundworm infections will have elevated levels of anti-A.
Reference Values
Interpretation depends on clinical setting.
Cautions
Decreased isoagglutinin titers may be seen in normal elderly individuals and in children ≤12 months.
This test is not useful for individuals with blood type A or AB.
Day(s) Performed
Monday through Sunday; Continuously
Report Available
1 dayPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test uses a standard method. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86886