Home
HelpTest ID BNP B-Type Natriuretic Peptide (BNP), Plasma
Useful For
Aids in the diagnosis of congestive heart failure (CHF)
The role of brain natriuretic peptide in monitoring CHF therapy is under investigation
Method Name
Immunoenzymatic Assay
Reporting Name
B-Type Natriuretic Peptide (BNP)Specimen Type
Plasma EDTACollection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Spin down, remove plasma from cells, and immediately freeze.
Additional Information: Include patient's age and sex.
Forms: If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
Oncology Test Request Form (T729) (http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)
Cardiovascular Test Request Form (T724) (http://www.mayomedicallaboratories.com/it-mmfiles/cardiovascular-request-form.pdf)
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma EDTA | Frozen | 365 days |
Clinical Information
B-type natriuretic peptide (brain natriuretic peptide; BNP) is a 32-amino acid-ringed peptide secreted by the heart to regulate blood pressure and fluid balance.(1) BNP is stored in and secreted predominantly from membrane granules in the heart ventricles, and is continuously released from the heart in response to both ventricle volume expansion and pressure overload.(2)
The natriuretic peptide system and the renin-angiotensin system counteract each other in arterial pressure regulation. When arterial pressure decreases, the kidneys release renin, which activates angiotensinogen resulting in increased peripheral resistance of the arterioles, thus increasing arterial pressure.
The natriuretic peptides counteract the effects of renin secretion, causing a reduction of blood pressure and in extracellular fluid volume.(3) Both BNP and atrial natriuretic peptide (ANP) are activated by atrial and ventricular distension due to increased intracardiac pressure. These peptides have both natriuretic and diuretic properties: they raise sodium and water excretion by increasing the glomerular filtration rate and inhibiting sodium reabsorption by the kidney.
The New York Heart Association (NYHA) developed a functional classification system for congestive heart failure (CHF) consisting of 4 stages based on the severity of the symptoms. Various studies have demonstrated that circulating BNP concentrations increase with the severity of CHF based on the NYHA classification.(4-6)
Reference Values
Males
≤45 years: ≤35 pg/mL
46 years: ≤36 pg/mL
47 years: ≤37 pg/mL
48 years: ≤38 pg/mL
49 years: ≤39 pg/mL
50 years: ≤40 pg/mL
51 years: ≤41 pg/mL
52 years: ≤42 pg/mL
53 years: ≤43 pg/mL
54 years: ≤45 pg/mL
55 years: ≤46 pg/mL
56 years: ≤47 pg/mL
57 years: ≤48 pg/mL
58 years: ≤49 pg/mL
59 years: ≤51 pg/mL
60 years: ≤52 pg/mL
61 years: ≤53 pg/mL
62 years: ≤55 pg/mL
63 years: ≤56 pg/mL
64 years: ≤57 pg/mL
65 years: ≤59 pg/mL
66 years: ≤60 pg/mL
67 years: ≤62 pg/mL
68 years: ≤64 pg/mL
69 years: ≤65 pg/mL
70 years: ≤67 pg/mL
71 years: ≤69 pg/mL
72 years: ≤70 pg/mL
73 years: ≤72 pg/mL
74 years: ≤74 pg/mL
75 years: ≤76 pg/mL
76 years: ≤78 pg/mL
77 years: ≤80 pg/mL
78 years: ≤82 pg/mL
79 years: ≤84 pg/mL
80 years: ≤86 pg/mL
81 years: ≤88 pg/mL
82 years: ≤91 pg/mL
≥83 years: ≤93 pg/mL
Females
≤45 years: ≤64 pg/mL
46 years: ≤66 pg/mL
47 years: ≤67 pg/mL
48 years: ≤69 pg/mL
49 years: ≤71 pg/mL
50 years: ≤73 pg/mL
51 years: ≤74 pg/mL
52 years: ≤76 pg/mL
53 years: ≤78 pg/mL
54 years: ≤80 pg/mL
55 years: ≤82 pg/mL
56 years: ≤84 pg/mL
57 years: ≤87 pg/mL
58 years: ≤89 pg/mL
59 years: ≤91 pg/mL
60 years: ≤93 pg/mL
61 years: ≤96 pg/mL
62 years: ≤98 pg/mL
63 years: ≤101 pg/mL
64 years: ≤103 pg/mL
65 years: ≤106 pg/mL
66 years: ≤109 pg/mL
67 years: ≤112 pg/mL
68 years: ≤114 pg/mL
69 years: ≤117 pg/mL
70 years: ≤120 pg/mL
71 years: ≤123 pg/mL
72 years: ≤127 pg/mL
73 years: ≤130 pg/mL
74 years: ≤133 pg/mL
75 years: ≤137 pg/mL
76 years: ≤140 pg/mL
77 years: ≤144 pg/mL
78 years: ≤147 pg/mL
79 years: ≤151 pg/mL
80 years: ≤155 pg/mL
81 years: ≤159 pg/mL
82 years: ≤163 pg/mL
≥83 years: ≤167 pg/mL
Cautions
Lack of elevations have been reported if congestive heart failure is very acute (first hour) or with ventricular inflow obstruction (hypertrophic obstructive cardiomyopathy, mitral stenosis, atrial myxoma).
Some patients who have been exposed to animal antigens, either in the environment or as part of treatment or imaging procedures, may have circulating antianimal antibodies present. These antibodies may interfere with the assay reagents to produce unreliable results.
Day(s) Performed
Monday through Friday; 6 a.m.-4 p.m.
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83880