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Test ID BUPMX Buprenorphine and Norbuprenorphine, Chain of Custody, Random, Urine

Method Name

Immunoassay/Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Ordering Guidance


This test is for situations that require the chain-of-custody process. For testing not requiring chain of custody, order BUPM / Buprenorphine and Norbuprenorphine, Random, Urine



Specimen Required


Supplies: Chain of Custody Kit (T282)

Container/Tube: Chain of custody kit containing specimen containers, seals, and required documentation.

Specimen Volume: 5 mL

Collection Instructions: Collect specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.


Reporting Name

Buprenorphine w/metabolite, CoC, U

Specimen Type

Urine

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
BUPMX Buprenorphine w/metabolite, CoC, U 69033-9

 

Result ID Test Result Name Result LOINC Value
56644 Buprenorphine Immunoassay Screen 58359-1
65215 Buprenorphine 3415-7
48297 Norbuprenorphine 49753-7
56645 Chain of Custody 77202-0

Forms

1. Chain of Custody Request is included in the Chain-of-Custody Kit (T282).

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.

Useful For

Monitoring of compliance of buprenorphine therapy

 

Detection and confirmation of the illicit use of buprenorphine

 

Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was always under the control of personnel involved with testing the specimen; this control implies that the opportunity for specimen tampering would be limited.

Testing Algorithm

Adulterants testing will be performed on all chain-of-custody urine samples as per regulatory requirements.

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

G0480

80348 (if appropriate for select payers)

Clinical Toxicology CPT Code Client Guidance

 

 

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes
ADLTX Adulterants Survey, CoC, U Yes Yes

Specimen Minimum Volume

1 mL

Reference Values

Negative

Positive results are reported with a quantitative result.

 

Cutoff concentrations:

 

Immunoassay Screen: 5 ng/mL

 

Liquid chromatography tandem mass spectrometry:

Buprenorphine: 5.0 ng/mL

Norbuprenorphine: 2.5 ng/mL