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Test ID CFIBR Cardiac Fibrinogen, Plasma

Useful For

Evaluating risk of atherosclerosis and adverse events related to atherosclerotic disease

Method Name

Immunoprecipitation

Reporting Name

Cardiac Fibrinogen, P

Specimen Type

Plasma EDTA

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Fasting (12 hours preferred but not required)

2. Spin down and separate plasma from cells within 4 hours of draw.

Forms: If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/cardiovascular-request-form.pdf).

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma EDTA Refrigerated (preferred) 7 days
  Frozen  30 days
  Ambient  72 hours

Clinical Information

Elevated plasma fibrinogen is a risk factor for cardiovascular disease.(1) Fibrinogen contributes to cardiovascular disease risk through a variety of mechanisms. Plasma viscosity is strongly influenced by fibrinogen concentrations. Fibrinogen is an acute-phase reactant indicative of chronic inflammatory status. Most importantly, fibrinogen and its enzymatic degradation product fibrin bind specifically to activated platelets to promote platelet aggregation and blood clotting.

 

Carotid intimamedia thickness, a radiological measure of atherosclerosis, is significantly correlated with plasma fibrinogen concentrations.(2) Addition of plasma fibrinogen measurement to a prognostic model for cardiovascular disease that includes age, gender, tobacco use, blood pressure, history of diabetes, high density lipoprotein, and total cholesterol significantly improves 10-year risk classification. Fibrinogen assessment in patients at intermediate risk according to conventional biomarkers significantly improves classification.(3)

 

Plasma fibrinogen concentrations can be significantly lowered by smoking cessation and increased physical activity.(4,5)

Reference Values

<340 mg/dL 1st quartile (low risk)

340-390 mg/dL 2nd quartile

391-450 mg/dL 3rd quartile

>450 mg/dL 4th quartile (high risk)

Cautions

To identify a coagulation disorder, FIB / Fibrinogen, Plasma is a more appropriate test.

Day(s) Performed

Monday through Friday; 8 a.m.

Report Available

Same day/1 day (not reported on Saturday or Sunday)

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

85385

NY State Approved

Yes