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Test ID CIDP Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum


Ordering Guidance


Multiple neurological phenotype-specific autoimmune/paraneoplastic evaluations are available. For more information as well as phenotype-specific testing options, refer to Autoimmune Neurology Test Ordering Guide.

 

For a list of antibodies performed with each evaluation, see Autoimmune Neurology Antibody Matrix.



Specimen Required


Patient Preparation:  For optimal antibody detection, specimen collection is recommended before initiation of immunosuppressant medication or intravenous immunoglobulin treatment.

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Reporting Name

CIDP/NP Evaluation, S

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Report Available

5 to 10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CIDP CIDP/NP Evaluation, S 101447-1

 

Result ID Test Result Name Result LOINC Value
614591 Neurofascin-155 IgG4, S 100845-7
616444 CIDP/NP Interpretation, S 69048-7
616442 Contactin-1 IgG CBA, S 101448-9

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.

Useful For

Evaluating for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and related demyelinating peripheral neuropathies

Day(s) Performed

CONCS: Monday through Thursday, Sunday

NF4FS: Monday, Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255 x 2

Specimen Minimum Volume

2 mL

Reference Values

CONTACTIN-1 IgG:

Negative

 

NEUROFASCIN 155 IgG4:

Negative

Method Name

CONCS: Cell Binding Assay (CBA)

NF4FS: Flow Cytometry (FCM)

CIDPI: Medical Interpretation

Profile Information

Test ID Reporting Name Available Separately Always Performed
CIDPI CIDP/NP Interpretation, S No Yes
CONCS Contactin-1 IgG CBA, S No Yes
NF4FS Neurofascin-155 IgG4, S No Yes

Testing Algorithm

A thorough understanding of a patient's history along with clinical examination and laboratory testing are needed for a clinico-sero-pathological diagnosis of chronic demyelinating polyradiculoneuropathy (CIDP). To assess the probability of your patient having CIDP vs mimic disorders, see the Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) calculator.