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HelpTest ID CMVP Cytomegalovirus (CMV) Antibodies, IgM and IgG, Serum
Useful For
Diagnosis of primary, acute phase infection with cytomegalovirus (CMV), especially in patients with infectious mononucleosis and pregnant women who, based on clinical signs or exposure, may have primary CMV infection
Determining whether a patient (especially transplant recipients, organ and blood donors) has had a recent infection or previous exposure to CMV
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CMVM | Cytomegalovirus Ab, IgM, S | Yes | Yes |
| CMVG | Cytomegalovirus Ab, IgG, S | Yes | Yes |
Method Name
Multiplex Flow Immunoassay (MFI)
Reporting Name
Cytomegalovirus Ab, IgM and IgG, SSpecimen Type
SerumContainer/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 1 mL
Specimen Minimum Volume
0.8 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days |
Clinical Information
Cytomegalovirus (CMV) is a member of the Herpesviridae family of viruses and usually causes asymptomatic infection after which it remains latent in patients, primarily within bone marrow derived cells.(1) Primary CMV infection in immunocompetent individuals may also manifest as a mononucleosis-type syndrome, similar to primary Epstein-Barr virus infection, with fever, malaise and lymphadenopathy.
CMV is a significant cause of morbidity and mortality among bone marrow or solid organ transplant recipients, individuals with AIDS and other immunosuppressed patients due to virus reactivation or from a newly acquired infection.(2,3) Infection in these patient populations can affect almost any organ and lead to multi-organ failure. CMV is also responsible for congenital disease among newborns and is 1 of the TORCH infections (toxoplasmosis, other infections including syphilis, rubella, CMV, and herpes simplex virus).
CMV seroprevalence increases with age. In the United States the prevalence of CMV specific antibodies increases from approximately 36% to over 91% in adolescents between the ages of 6 to 11 and adults over 80 years old, respectively.(4)
Reference Values
CMV IgM:
Negative (reported as positive, negative, or equivocal)
CMV IgG:
Negative (reported as positive, negative, or equivocal)
Cautions
Sera drawn very early during the acute stage of infection may have undetectable levels of cytomegalovirus (CMV) IgM or IgG.
Immunocompromised patients may have impaired immune responses and non-reactive IgM/IgG results may be due to delayed seroconversion and do not rule out current infection.
The CMV IgM and IgG results should not be used alone to diagnose CMV infection. Results should be considered in conjunction with clinical presentation, patient history and other laboratory findings. In cases of suspected disease, submit a second sample for testing in 10 to 14 days.
The performance characteristics of these assays have not been evaluated in immunosuppressed or organ transplant recipients and have not been established for cord blood or for testing of neonates. These assays should not be used for screening blood or plasma donors.
Immune complexes or other immunoglobulin aggregates present in patient samples may cause increased non-specific binding and produce false-positive results.
Potential cross-reactivity for CMV IgM may occur with specimens positive for Epstein-Barr virus viral capsid antigen IgM and parvovirus B19 IgM.
Potential cross-reactivity for CMV IgG with human chorionic gonadotropin, HIV IgG, multiple myeloma IgG, rheumatoid factor IgM, and Toxoplasma gondii IgG have not be ruled out.
Day(s) Performed
Monday through Saturday; Varies
Report Available
Same day/1 dayPerforming Laboratory
Mayo Medical Laboratories in Rochester
CPT Code Information
86644-CMV
86645-CMV, IgM