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Test ID CVRMP Cardiovascular Risk Marker Panel, Serum

Useful For

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

Profile Information

Test ID Reporting Name Available Separately Always Performed
NOHDL Non-HDL Cholesterol No Yes
CALDL Calculated LDL No Yes
HDCDC HDL Cholesterol, CDC, S Yes, (order HDCH) Yes
TCCDC Cholesterol, Total, CDC, S Yes, (order CHOL) Yes
TGCD1 Triglycerides, Total, CDC, S Yes, (order TRIG) Yes
CVINT Interpretation No Yes
LIPA Lipoprotein (a), S Yes Yes
HSCRP C-Reactive Protein, High Sens, S Yes Yes

Method Name

LIPA, HSCRP: Automated Turbidimetric Immunoassay

TCCDC, TGCD1, HDCDC, NOHDL, CALDL: Selective Precipitation/Enzymatic Colorimetry/Friedewald Equation

Reporting Name

Cardiovascular Risk Marker Panel, S

Specimen Type

Serum

Specimen Type: Serum

Container/Tube: Serum gel

Specimen Volume: 2.5 mL 

Collection Instructions: Fasting-overnight (12-14 hour). Patient must not consume any alcohol for 24 hours before the specimen is drawn.

Forms: If not ordering electronically, complete, print, and send a Cardiovascular Test Request Form (T724) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/cardiovascular-request-form.pdf)

Specimen Minimum Volume

1.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Clinical Information

Cardiovascular disease is the number 1 cause of death in the United States with an estimated 1.5 million heart attacks and 0.5 million strokes occurring annually. Many of these events occur in individuals who have no prior symptoms. Standard risk factors, including age, smoking status, hypertension, diabetes, cholesterol, and HDL cholesterol, predict only about 65% of individuals who will go on to have a cardiovascular event. Therefore, identification of patients with residual risk is important to target lifestyle and pharmaceutical intervention to those at higher risk of future events.

 

Many additional risk markers have been identified for cardiovascular disease but few have emerged as independent risk markers. Two of these additional risk markers, high-sensitivity C-reactive protein (hsCRP) and lipoprotein (a) (Lp[a]), are clearly shown to be independently associated with increased risk of future cardiovascular events. Several recent guidelines have suggested that clinicians utilize hsCRP and Lp(a) in selected persons to augment risk classification, guide intensity of risk-reduction therapy and modulate clinical judgment when making therapeutic decision.(1-3) Prospective studies assessing these risk factors individually have determined them to be independently associated with increased risk for the development of ischemic events.

 

Guidelines recommend measurement of additional risk markers in individuals who are at intermediate risk for developing cardiovascular disease, those with early atherosclerosis without explanation by abnormalities of traditional risk factors, and those with a strong family history of cardiovascular disease without the presence of traditional risk factors.

Reference Values

Reference values apply to fasting specimens only.

 

Non-HDL CHOLESTEROL

2 to 17 years**

Acceptable: <110 mg/dL

Borderline high: 110-129 mg/dL

High: ≥130 mg/dL

 

≥18 years*

Desirable: <130 mg/dL

Above Desirable: 130-159 mg/dL

Borderline high: 160-189 mg/dL

High: 190-219 mg/dL

Very high: ≥220 mg/dL

 

LDL CHOLESTEROL

2 to 17 years**

Acceptable: <110 mg/dL

Borderline high: 110-129 mg/dL

High: ≥130 mg/dL

 

≥18 years*

Desirable: <100 mg/dL

Above Desirable: 100-129 mg/dL

Borderline high: 130-159 mg/dL

High: 160-189 mg/dL

Very high: ≥190 mg/dL

 

HDL CHOLESTEROL

Males:

2 to 17 years**

Low: <40 mg/dL

Borderline low: 40-45 mg/dL

Acceptable: > 45 mg/dL

≥18 years*: ≥40 mg/dL

 

Females

2 to 17 years**

Low: <40 mg/dL

Borderline low: 40-45 mg/dL

Acceptable: > 45 mg/dL

≥18 years*: ≥ 50 mg/dL

 

TOTAL CHOLESTEROL

2 to 17 years**

Acceptable: <170 mg/dL

Borderline high: 170-199 mg/dL

High: ≥200 mg/dL

 

≥18 years***

Desirable: <200 mg/dL

Borderline high: 200-239 mg/dL

High: ≥240 mg/dL

 

TRIGLYCERIDES

2 to 9 years**

Acceptable: <75 mg/dL

Borderline high: 75-99 mg/dL

High: ≥100 mg/dL

 

10 to 17 years**

Acceptable: <90 mg/dL

Borderline high: 90-129 mg/dL

High: ≥130 mg/dL

 

≥18 years*

Normal: <150 mg/dL

Borderline high: 150-199 mg/dL

High: 200-499 mg/dL

Very high: ≥500 mg/dL

 

LIPOPROTEIN (a)

≤30 mg/dL

Values >30 mg/dL may suggest increased risk of coronary heart disease.

 

C-REACTIVE PROTEIN HIGH SENSITIVITY*

Lower risk: <2.0 mg/L

Higher risk: ≥2.0 mg/L

Acute inflammation: >10.0 mg/L

 

*National Lipid Association 2014

**Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents

***National Cholesterol Education Program (NCEP)

Cautions

Patients must be fasting for at least 12 to 14 hours.

 

Lipid values should be considered in the context of clinical presentation. Additional risk factors include cigarette smoking, hypertension, age and personal or family history of cardiovascular disease.

 

Result can be falsely decreased in patients with elevated levels of N-acetyl-p-benzoquinone imine (NAPQI)-a metabolite of acetaminophen, N-acetylcysteine (NAC), and metamizole.

Day(s) Performed

Monday through Friday; Continuously

Report Available

Same day/1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478])

83695-Lipoprotein (a)

86141-C-reactive protein; high sensitivity (hsCRP)

NY State Approved

Yes