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Test ID CZPS Clonazepam and 7-Aminoclonazepam, Serum

Test Down Notes

Effective December 14, 2023:  This test is temporarily unavailable due to analytic issues.  The downtime is expected to be >30 days.  Order FCLMS as an alternate.  See test notification here.


Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.2 mL

Collection Instructions:

1. Draw blood immediately before next scheduled dose (minimum 12 hours after last dose).

2. Within 2 hours of collection, the specimen must be centrifuged and the serum aliquoted into a plastic vial.


Reporting Name

Clonazepam and 7-Aminoclonazepam, S

Specimen Type

Serum Red

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CZPS Clonazepam and 7-Aminoclonazepam, S 104541-8

 

Result ID Test Result Name Result LOINC Value
65044 Clonazepam 3494-2
41782 7-Aminoclonazepam 28059-4

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Therapeutics Test Request (T831)

-Neurology Specialty Testing Client Test Request (T732)

Useful For

Assessing patient compliance

 

Monitoring for appropriate therapeutic level

 

Assessing clonazepam toxicity

Day(s) Performed

Monday, Wednesday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

Specimen Minimum Volume

0.6 mL

Reference Values

Clonazepam

Anticonvulsant: 20-70 ng/mL

Anxiolytic: 4-80 ng/mL

Some individuals may show therapeutic response outside of these ranges or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 

Note: Therapeutic ranges are for specimens collected at trough (ie, immediately before next scheduled dose). Levels may be elevated in non-trough specimens.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)