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HelpTest ID DMOGA Monoclonal Gammopathy, Diagnostic, Serum
Ordering Guidance
To monitor a patient with an established diagnosis of a monoclonal gammopathy, order TMOGA / Monoclonal Gammopathy, Monitoring, Serum.
Specimen Required
Patient Preparation: Fasting (12 hour) preferred but not required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container /Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot into a plastic vial.
Useful For
Screening and diagnosing monoclonal gammopathies including analysis of free light chains
Assessing the risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| TMAB | Therapeutic Antibody Administered? | No | Yes |
| TPE | Total Protein | Yes, (Order TP) | Yes |
| SPE | Protein Electrophoresis | No | Yes |
| MPTS | M-protein Isotype MALDI-TOF MS, S | Yes, (Order MALD) | Yes |
| KFLCS | Kappa Free Light Chain, S | Yes, (Order FLCS) | Yes |
| LFLCS | Lambda Free Light Chain, S | Yes, (Order FLCS) | Yes |
| KLRS | Kappa/Lambda FLC Ratio | Yes, (Order FLCS) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IFXED | Immunofixation Delta and Epsilon, S | Yes | No |
Testing Algorithm
This test includes total protein, serum protein electrophoresis, heavy and light chain typing (kappa and lambda), and quantitation of kappa and lambda free light chains.
If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.
For more information see:
Special Instructions
Method Name
TMAB: Patient Information
TPE: Colorimetric; Biuret
SPE: Agarose Gel Electrophoresis
MPTS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)
KFLCS, LFLCS: Turbidimetry
KLRS: Calculation
Reporting Name
Monoclonal Gammopathy Diagnostic, SSpecimen Type
SerumSpecimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 72 hours |
Reference Values
TOTAL PROTEIN:
≥1 year: 6.3-7.9 g/dL
Reference values have not been established for patients that are younger than 12 months of age.
PROTEIN ELECTROPHORESIS
Albumin: 3.4-4.7 g/dL
Alpha-1-globulin: 0.1-0.3 g/dL
Alpha-2-globulin: 0.6-1.0 g/dL
Beta-globulin: 0.7-1.2 g/dL
Gamma-globulin: 0.6-1.6 g/dL
An interpretive comment is provided with the report.
Reference values have not been established for patients that are younger than 16 years of age.
M-PROTEIN ISOTYPE MALDI-TOF MS
No monoclonal protein detected
M-protein Isotype MALDI-TOF MS Flag
Negative
KAPPA-FREE LIGHT CHAIN
0.33-1.94 mg/dL
LAMBDA-FREE LIGHT CHAIN
0.57-2.63 mg/dL
KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO
0.26-1.65
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83521 x 2
84155
84165
0077U
86334 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DMOGA | Monoclonal Gammopathy Diagnostic, S | 90992-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TPE | Total Protein | 2885-2 |
| 602837 | Albumin | 2862-1 |
| LFLCS | Lambda Free Light Chain, S | 33944-0 |
| KLRS | Kappa/Lambda FLC Ratio | 48378-4 |
| TMAB | Therapeutic Antibody Administered? | 98855-0 |
| KFLCS | Kappa Free Light Chain, S | 36916-5 |
| 65198 | M-protein Isotype MALDI-TOF MS | 90990-3 |
| 606976 | Flag, M-protein Isotype | 94400-9 |
| 602838 | Alpha-1 Globulin | 2865-4 |
| 602839 | Alpha-2 Globulin | 2868-8 |
| 602840 | Beta-Globulin | 2871-2 |
| 602841 | Gamma-Globulin | 2874-6 |
| 602842 | A/G Ratio | 44429-9 |
| 602843 | M spike | 51435-6 |
| 602844 | M spike | 35559-4 |
| 602836 | Impression | 49296-7 |