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Test ID EBVA Epstein-Barr Virus (EBV), IgA, Serum

Useful For

The test is indicated for patients with malignant lesions of type 2 and 3 in whom nasopharyngeal carcinoma is suspected; eg, patients with metastases to the cervical lymph nodes from an unknown primary source.

Method Name

Immunofluorescence Assay (IFA)

Reporting Name

Epstein-Barr Virus (EBV), IgA, S

Specimen Type

Serum

Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.2 mL

Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Clinical Information

Infection with Epstein-Barr virus (EBV) usually occurs early in life. For several weeks to months after acute onset of the infection, it is spread by upper respiratory secretions that contain the virus.

 

Among the clinical disorders due to EBV infections, infectious mononucleosis is most common. Other disorders due to EBV infection have been recognized for several years, including African-type Burkitt lymphoma and nasopharyngeal carcinoma (NPC). The World Health Organization (WHO) classifies NPC as type 1 (keratinizing squamous cell carcinoma), type 2 (nonkeratinizing squamous cell carcinoma), and type 3 (undifferentiated carcinoma).

 

EBV infection also may cause lymphoproliferative syndromes, especially in patients who have undergone renal or bone marrow transplantation and in those who have AIDS.

Reference Values

<1:10

Cautions

It should be noted that there are some patients with nasopharyngeal carcinoma whose serum will contain antibodies to the early antigen (EBVE / Epstein-Barr Virus [EBV], IgG Antibody to Early Antigen, Serum) of the virus but not antibodies to the viral capsid antigen and vice versa.

Day(s) Performed

Wednesday; 9 a.m.

Report Available

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

86665

NY State Approved

Yes