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HelpTest ID EEPC Eastern Equine Encephalitis Antibody Panel, IgG and IgM, Spinal Fluid
Ordering Guidance
This assay detects Eastern equine antibodies only. For a complete arbovirus panel, order ABOPC / Arbovirus Antibody Panel, IgG and IgM, Spinal Fluid.
New York State clients: This test is not available for specimens originating in New York.
Specimen Required
Container/Tube: Sterile vial
Preferred: Vial number 1
Acceptable: Any vial
Specimen Volume: 0.8 mL
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.
Useful For
Aiding in the diagnosis of Eastern equine encephalitis using spinal fluid specimens
Testing Algorithm
For more information see Mosquito-borne Disease Laboratory Testing
Special Instructions
Method Name
Immunofluorescence Assay (IFA)
Reporting Name
East Equine Enceph Ab Panel, CSFSpecimen Type
CSFSpecimen Minimum Volume
0.7 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Clinical Information
Eastern equine encephalitis (EEE) is within the alphavirus group. It is a low-prevalence cause of human disease in the Eastern and Gulf Coast states. EEE is maintained by a cycle of mosquito/wild bird transmission, peaking in the summer and early fall, when humans may become an adventitious host. The most common clinically apparent manifestation is a mild undifferentiated febrile illness, usually with headache.
Central nervous system involvement is demonstrated in only a minority of infected individuals and is more abrupt and more severe than with other arboviruses, with children being more susceptible to severe disease. Fatality rates are approximately 70% EEE.
Infections with arboviruses can occur at any age. The age distribution depends on the degree of exposure to the particular transmitting arthropod, relating to age, sex, and occupational, vocational, and recreational habits of the individuals. Once humans have been infected, the severity of the host response may be influenced by age.
Reference Values
IgG: <1:1
IgM: <1:1
Reference values apply to all ages.
Cautions
All results must be correlated with clinical history and other data available to the attending physician.
False-positive results may be caused by breakdown of the blood-brain barrier, or by the introduction of blood into the cerebrospinal fluid at collection.
Eastern equine encephalitis viruses show some cross-reactivity; however, antibody response to the infection virus is typically at least 8-fold higher.
Day(s) Performed
May through October: Monday through Friday
November through April: Monday, Wednesday, Friday
Report Available
Same day/1 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86652 x 2