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Test ID F17HP 17-Hydroxy Progesterone, Urine

Method Name

Radioimmunoassay (RIA)

Reporting Name

17-Hydroxy Progesterone, U

Specimen Type

Urine

10 mL from a 24-hour urine collection. No special preservative required: hydrochloric acid and boric acid are acceptable Refrigerate  specimen during collection. Send specimen frozen in plastic bottle.

 

Note:    1. Patient should not be on any Corticosteroid, ACTH, steroid, estrogen, or gonadotropin medication, if possible, for at least 48 hours prior to start of urine collection.

            2. Duration and total volume required.

Specimen Minimum Volume

5 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 180 days
  Refrigerated  7 days

Clinical Information

17-Hydroxy Progesterone is a steroid derived primary from enzymatic

metabolism of Progesterone and 17-Hydroxy Pregnenolone. It is converted

enzymatically to Androstenedione and 11-Deoxycortisol. It is produced

in both the gonads and adrenal glands. It is excreted into the urine in

conjugated and unconjugated forms of 17-Hydroxy Progesterone and

as Pregnanetriol. This assay measures the total of the conjugated and

unconjugated forms. It is stimulated by ACTH and suppressed by

Dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly

increased in patients with Polycystic Ovarian Disease and Congenital

Adrenal Hyperplasia and show exaggerated responses to ACTH in

these cases. 17-Hydroxy Progesterone is the marker steroid for

determining cases of 21a-Hydroxylase Deficient Congenital Adrenal

Hyperplasia. Urine levels are frequently elevated in patients with

idiopathic hirsutism.

Reference Values

Pediatric Reference Ranges:

Newborns and Infants: 3 days to 1 year:  Up to 50 ng/24 hrs

Children: 1 - 8 years:  Up to 300 ng/24 hrs

 

Adult Reference Ranges:

Male:  Up to 2.0 ug/24 hrs.

Female: Up to 4.5 ug/24 hrs.

 

Day(s) Performed

Monday through Friday

Report Available

5 - 7 days

Performing Laboratory

Inter Science Institute

Test Classification

This test was performed using a kit that has been approved by the FDA for an alternate matrix. The analytic performance characteristics of this test for the submitted matrix have been determined by Inter Science Institute.

CPT Code Information

83498

NY State Approved

No