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Test ID FBBAB Lyme Disease Antibody Index for CNS Infection

Profile Information

Test ID Reporting Name Available Separately Always Performed
FZ003 Lyme Disease Ab Index No Yes
FZ004 Albumin Ratio No No

Method Name

Enzyme Linked Immunosorbent Assay (ELISA) and Nephelometry (NEPH)

Reporting Name

Lyme Disease Ab for CNS Infection

Specimen Type

CSF
Serum

Requires Serum AND CSF

 

Draw blood in a red-top tube(s) (Serum gel tube is acceptable.) Spin down and submit 2 mL refrigerate serum.

 

Collect 2 mL CSF in a sterile plastic vial and submit refrigerate.

 

Note:    Serum and CSF must be drawn within 24 hours of each other.

Specimen Minimum Volume

1 mL serum AND 1 mL CSF

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  7 days
Serum Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  7 days

Reference Values

Lyme Disease Antibody Index:

        ≤ 1.0  Negative

        1.1 - 1.2     Equivocal

        ≥ 1.3  Positive

      

Control Antibody Index: ≤ 1.0

      

Albumin Ratio:  <0.0078

      

The Lyme Disease Antibody Index is used as an aid for the diagnosis of neuroborreliosis. An increased Lyme Disease Antibody Index (>1.2), accompanied by a Control Antibody Index of less than 1.0 and an Albumin Ratio of less than 0.0078, is strong evidence for intrathecal synthesis of organism-specific antibody, and thus CNS B. burgdorferi infection. Elevation of either the control antibody index, the Albumin Ratio, or both may indicate leakage of antibody across the blood-brain barrier which may falsely elevate the Lyme Disease Antibody Index.

 

Day(s) Performed

Tuesday and Friday

Report Available

1 week

Performing Laboratory

Focus Diagnositics, Inc.

CPT Code Information

82040

82042

82784/x2

86618/x4

NY State Approved

Yes