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HelpTest ID FCAH1 CAH Pediatric Profile 1, 21-OH Deficiency Screen (Androstene-dione, Cortisol, DHEA, 17-OH-Progesterone, Testosterone)
Method Name
Radioimmunoassay (RIA)
High Performance Liquid Chromatography/Tandem Mass
Spectrometry (LC-MS/MS)
Reporting Name
CAH Profile 1Specimen Type
SerumDraw blood in a plain, red-top tube(s) or serum gel tube(s). Separate within one hour of draw and send 2 mL of serum frozen in plastic vial on dry ice. Specimens drawn in serum gel tube(s) must be poured off into a plastic screw cap vial before freezing.
Specimen Minimum Volume
1 mL
NOTE: Minimum volume does not allow for
repeat analysis
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen | 30 days |
Reference Values
Androstenedione, Mass Spec
Units: ng/dL
Age Range
Premature (26-28w) Day 4 63-935
Premature (31-35w) Day 4 50-449
Full Term (1-7 days) <10-279
Levels decrease rapidly to <52 ng/dL after one week.
1m-11m <10-37
Androstenedione gradually decreases during the first six months to prepubertal levels.
Prepubertal Children <10-17
Adult Males 44-186
Adult Females 28-230
Females Postmenopausal <10-93
Females
Tanner Stages Age (years) Range
1 <9.2 <10-17
2 9.2-13.7 <10-72
3 10.0-14.4 50-170
4 10.7-15.6 47-208
5 11.8-18.6 50-224
Males
Tanner Stages Age (years) Range
1 <9.8 <10-17
2 9.8-14.5 <10-33
3 10.7-15.4 17-72
4 11.8-16.2 15-115
5 12.8-17.3 33-192
Cortisol, Serum or Plasma
Units: ug/dL
Age Range
Premature (26-28w) Day 4 1.0 - 11
Premature (31-35w) Day 4 2.5 - 9.1
Full Term Day 3 1.7 - 14
Full Term Day 7 2.0 - 11
31d - 11m 2.8 - 23
12m - 15y (8:00 AM) 3.0 - 21
Adults
8:00 AM 8.0 - 19
4:00 PM 4.0 - 11
Dehydroepiandrosterone (DHEA), Serum
Units: ng/dL
Age Range
1-5 yrs <68
6-7 yrs <111
8-10 yrs <186
11-12 yrs <202
13-14 yrs <319
15-16 yrs 39-481
17-19 yrs 40-491
20-49 yrs 31-701
≥ 50 yrs 21-402
17-Alpha-Hydroxyprogesterone, Serum
Units: ng/dL
Age Range
Premature (26-28w) Day 4 124 - 841
Premature (31-35w) Day 4 26 - 568
Full-Term Day 3 <78
Males: Levels increase after the first week to peak values ranging from 40 - 200 between 30 and 60 days. Values then decline to a prepubertal value of <91 before one year.
Prepubertal <91
Adult Males 27 - 199
Females
1 - 11m 13 - 106
Prepubertal <91
Adult Females
Follicular 15 - 70
Luteal 35 - 290
Females
Tanner Stages Age (years) Range
1 <9.2 <83
2 9.2-13.7 11-98
3 10.0-14.4 11-155
4 10.7-15.6 18-230
5 11.8-18.6 20-265
Males
Tanner Stages Age (years) Range
1 <9.8 <91
2 9.8-14.5 <116
3 10.7-15.4 10-138
4 11.8-16.2 29-180
5 12.8-17.3 24-175
Testosterone, Serum (Total)
Units: ng/dL
Age Range
Males
Premature (26-28w) Day 4 59 - 125
Premature (31-35w) Day 4 37 - 198
Newborns 75 - 400
1 - 7m: Levels decrease rapidly the first week to 20 - 50, then increase to 60 - 400 between 20 - 60 days. Levels then decline to prepubertal range levels of <2.5 - 10 by seven months.
Females
Premature (26 - 28w) Day 4 5 - 16
Premature (31 - 35w) Day 4 5 - 22
Newborns 20 - 64
1 - 7m: Levels decrease during the first month to less than 10 and remain there until puberty.
Prepubertal Males and Females <2.5 - 10
Adult Males >18 years 348 - 1197
Adult Females
Premenopausal: 10 - 55
Postmenopausal: 7 - 40
Males
Tanner Stage Age (years) Male
1 <9.8 <2.5 – 10
2 9.8 – 14.5 18 – 150
3 10.7 – 15.4 100 – 320
4 11.8 – 16.2 200 – 620
5 12.8 – 17.3 350 – 970
Females
Tanner Stage Age (years) Female
1 <9.2 <2.5 – 10
2 9.2 – 13.7 7 – 28
3 10.0 – 14.4 15 – 35
4 10.7 – 15.6 13 – 32
5 11.8 – 18.6 20 - 38
Day(s) Performed
Monday, Tuesday, Thursday
Report Available
3 - 6 daysPerforming Laboratory
Esoterix EndocrinologyCPT Code Information
82157/Androstenedione
82533/Cortisol
82626/DHEA
83498/17-OH-Progesterone
84403/Testosterone