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HelpTest ID FCAH4 CAH Pediatric Profile 4: 3B-HSD Deficiency Screen (Androsten-edione, Cortisol, DHEA, 17-OH-Pregnenolone, 17-OH-Proges-terone)
Method Name
Radioimmunoassay (RIA)
High Performance Liquid Chromatography/Tandem Mass
Spectrometry (LC-MS/MS)
Reporting Name
CAH Profile 4Specimen Type
SerumDraw blood in a plain, red-top tube(s) or a serum gel tube(s). Separate within one hour and send 1.5 mL of serum frozen in plastic vial. Specimens drawn in serum gel tube(s) must be poured off into a plastic screw cap vial before freezing.
Specimen Minimum Volume
0.8 mL
Note: Minimum volume does not allow for repeat analysis.
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen | 30 days |
Reference Values
Androstenedione
Units: ng/dL
Age Range
Premature (26-28w) Day 4 63-935
Premature (31-35w) Day 4 50-449
Full Term (1-7 days) <10-279
Levels decrease rapidly to <52 ng/dL after one week.
1m-11m <10-37
Androstenedione gradually decreases during the first six months to prepubertal levels.
Prepubertal Children <10-17
Adult Males 44-186
Adult Females 28-230
Females Postmenopausal <10-93
Females
Tanner Stages Age (years) Range
1 <9.2 <10-17
2 9.2-13.7 <10-72
3 10.0-14.4 50-170
4 10.7-15.6 47-208
5 11.8-18.6 50-224
Males
Tanner Stages Age (years) Range
1 <9.8 <10-17
2 9.8-14.5 <10-33
3 10.7-15.4 17-72
4 11.8-16.2 15-115
5 12.8-17.3 33-192
Cortisol
Units: ug/dL
Age Range
Premature (26-28w) Day 4 1.0 - 11
Premature (31-35w) Day 4 2.5 - 9.1
Full Term Day 3 1.7 - 14
Full Term Day 7 2.0 - 11
31d - 11m 2.8 - 23
12m - 15y (8:00 AM) 3 .0 - 21
Adults
8:00 AM 8.0 - 19
4:00 PM 4.0 - 11
Dehydroepiandrosterone (DHEA)
Units: ng/dL
Age Range
1-5 yrs <68
6-7 yrs <111
8-10 yrs <186
11-12 yrs <202
13-14 yrs <319
15-16 yrs 39-481
17-19 yrs 40-491
20-49 yrs 31-701
≥ 50 yrs 21-402
17-OH Pregnenolone
Units: ng/dL
Age Range
Premature (26-28w) Day 4 375 - 3559
Premature (31-35w) Day 4 64 - 2380
3 Days 10 - 829
1 - 5m 36 - 763
6 - 11m 42 - 540
12 - 23m 14 - 207
24m - 5y 10 - 103
6 - 9y 10 - 186
Pubertal 44 - 235
Adults 53 - 357
17-Alpha-Hydroxyprogesterone
Units: ng/dL
Age Range
Premature (26-28w) Day 4 124 - 841
Premature (31-35w) Day 4 26 - 568
(if no age submitted):
Full-Term Day 3 <78
Males: Levels increase after the first week to peak values ranging from 40 - 200 between 30 and 60 days. Values then decline to a prepubertal value of <91 before one year.
Prepubertal <91
Adult Males 27 - 199
Females
1 - 11m 13 - 106
Prepubertal <91
Adult Females
Follicular 15 - 70
Luteal 35 - 290
Females
Tanner Stages Age (years) Range
1 <9.2 <83
2 9.2-13.7 11-98
3 10.0-14.4 11-155
4 10.7-15.6 18-230
5 11.8-18.6 20-265
Males
Tanner Stages Age (years) Range
1 <9.8 <91
2 9.8-14.5 <116
3 10.7-15.4 10-138
4 11.8-16.2 29-180
5 12.8-17.3 24-175
Day(s) Performed
Monday, Tuesday, Thursday
Report Available
3 - 6 daysPerforming Laboratory
Esoterix EndocrinologyCPT Code Information
82157/Androstenedione
82533/Cortisol
82626/DHEA
83498/17-OH-Progesterone
84143/17-OH-Pregnenolone