Home
HelpTest ID FGNRH Gonadotropin Releasing Hormone (Gn-RH, Luteinizing Hormone-Releasing Hormone LH-RH)
Specimen Required
Patient preparation:
Patient should not be on any Steroid, ACTH, Gonadotropin, or Estrogen medications, if possible, for at least 48 hours prior to collection of specimen.
Specimen Type: Serum
Container/Tube: Red top or SST
Specimen Volume: 3 mL
Collection Instructions: Draw blood in a plain, red-top tube(s), serum-gel tube(s) is acceptable. Separate immediately and send 3 mL of serum frozen in a plastic vial.
Secondary ID
90165Method Name
Direct Radioimmunoassay
Reporting Name
Gonadotropin Releasing HormoneSpecimen Type
SerumSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen (preferred) | 180 days |
| Refrigerated | 7 days |
Clinical Information
Gonadotropin-Releasing Hormone (Gn-RH), also known as Luteinizing Hormone-Releasing Hormone (LH-RH), is a decapeptide secreted pulsatily from the hypothalamus. It stimulates the release of the Gonadotropins - Luteinizing Hormone and Follicle Stimulating Hormone - exerting a stronger effect on Luteinizing Hormone. Testosterone and Estradiol, whose release is stimulated by the Gonadotropins, exert a negative feedback control on LH-RH both at the hypothalamic site and by decreasing pituitary receptor binding. LH-RH levels are low in patients with hypothalamic hypogonadism differentiating them from the high levels usually found in primary hypopituitary hypogonadism. Accentuation of the LH-RH pulse occurs at the onset of puberty triggering the release of LH and FSH required in pubertal development. LH-RH is stimulated by Epinephrine and suppressed by Dopamine and opiates. LH-RH and some of its agonists are frequently used to induce ovulation.
Reference Values
Adult Reference Range(s):
Males: 4.0 - 8.0 pg/mL
Females: 2.0 - 10.0 pg/mL
No pediatric reference ranges available for this test.
Day(s) Performed
Monday through Friday
Report Available
7 to 11 daysPerforming Laboratory
Inter Science InstituteTest Classification
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.CPT Code Information
83727