Sign in →

Test ID FGNRH Gonadotropin Releasing Hormone (Gn-RH)

Method Name

Direct Radioimmunoassay (RIA)

Reporting Name

Gonadotropin Releasing Hormone

Specimen Type

Varies

Submit only 1 of the following specimens:

 

Serum

Draw blood in a plain, red-top  or serum-gel tube(s). Separate immediately and send 3 mL of serum frozen in a plastic vial.

Note:    1. Indicate serum on request form.

            2. Label specimen appropriately (serum).

 

Plasma

Draw blood in a lavender-top (EDTA) tube(s). Separate immediately and send 3 mL of EDTA plasma frozen in a plastic vial.

Note:    1. Indicate plasma on request form.

            2. Label specimen appropriately (plasma).

 

Patient preparation:

            Patient should not be on any Steroid, ACTH, Gonadotropin, or Estrogen medications, if possible, for at least 48 hours prior to collection.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Varies Frozen (preferred) 180 days
  Refrigerated  7 days

Clinical Information

Gonadotropin-Releasing Hormone (Gn-RH), also known as Luteinizing Hormone-Releasing Hormone (LH-RH), is a Decapeptide secreted pulsatily from the hypothalamus. It stimulates the release of the Gonadotropins - Luteinizing Hormone and Follicle Stimulating Hormone - exerting a stronger effect on Luteinizing Hormone. Testosterone and Estradiol, whose release is stimulated by the Gonadotropins, exert a negative feedback control on LH-RH both at the hypothalamic site and by decreasing pituitary receptor binding. LH-RH levels are low in patients with hypothalamic hypogonadism differentiating them from the high levels usually found in primary hypopituitary hypogonadism. Accentuation of the LH-RH pulse occurs at the onset of puberty triggering the release of LH and FSH required in pubertal development. LH-RH is stimulated by Epinephrine and suppressed by Dopamine and opiates. LH-RH and some of its agonists are frequently used to induce ovulation.  

Reference Values

Adult Reference Range(s):

 

Males:  4.0 - 8.0 pg/mL

Females:  2.0 - 10.0 pg/mL

 

Day(s) Performed

Monday through Friday

Report Available

5 - 7 days

Performing Laboratory

Inter Science Institute

Test Classification

This test was developed and it's performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.

CPT Code Information

83727

NY State Approved

No