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Test ID FHAN Hantavirus Antibodies (IgG, IgM) with Reflex to Confirmation

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FSING Sin Nombre Virus IgG Confirmation No No
FSINM Sin Nombre Virus IgM Confirmation No No

Testing Algorithm

If Hantavirus IgG is ≥2.00 and Hantavirus IgM is ≥2.00 (FSING) Sin Nombre Virus IgG Confirmation will be performed at an additional charge.

 

If Hantavirus IgM is ≥2.00 (FSINM) Sin Nombre Virus IgM Confirmation will be performed at an additional charge.

Method Name

ELISA

Reporting Name

Hantavirus IgG, IgM w/Rfl

Specimen Type

Serum

Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  5 days

Reference Values

Reference Range:          <2.00

 

Interpretive Criteria:

                                    <2.00                Antibody not detected

≥ 2.00        Antibody detected

    

Two major groups of hantaviruses are recognized based on clinical presentation. The first group includes Sin Nombre Virus (SNV), which causes hantavirus pulmonary syndrome, a severe and sometimes fatal form of acute respiratory distress. A second group of hantaviruses (including Seoul, Hantaan, Dobrava, and Puumala) causes hemorrhagic fever with renal syndrome, a condition not typically seen in the United States.

 

Sera are initially screened for IgG and IgM antibodies recognizing the nucleocapsid protein common to all hantaviruses. All screen IgM positive samples are then tested for SNV-specific IgM; any screen IgM positive samples that are also screen IgG positive are tested for SNV-specific IgG, as well as SNV-specific IgM. Samples that are screen IgG positive but screen IgM negative are not subjected to SNV-specific IgG testing, since the lack of IgM rules out acute SNV infection.

 

A positive screening result but a negative SNV-specific antibody result may indicate either reactivity to a hantavirus other than SNV or false positive reactivity. A small number of SNV IgM positive (but screen IgG negative) samples represent false positive reactivity associated with acute cytomegalovirus or Epstein Barr virus infection.

Day(s) Performed

Monday through Saturday

Report Available

1 - 3 days

Performing Laboratory

Focus Diagnositics, Inc.

Test Classification

This test was developed and its performance characteristics have been determined by Focus Diagnostics. Performance characteristics refer to the analytical performance of the test.

CPT Code Information

86790/x2 

86790/IgG confirm (if appropriate)

86790/IgM confirm (if appropriate)

NY State Approved

Yes