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Test ID FNEUR Neurotensin

Method Name

Direct Radioimmunoassay (RIA)

Reporting Name

Neurotensin

Specimen Type

Plasma

Collect 10 mL of blood in special Z-tube (MML supply number T701). Specimen should be separated and 3 mL plasma frozen as soon as possible.

 

Patient preparation:

            1)  Patient should be fasting 10-12 hours prior to collection.

            2)  Patient should not be on any antacid medication or medications that affect gastroentero-intestinal function, if possible, for at least 48 hours prior to collection.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Frozen 30 days

Clinical Information

Neurotensin is a 13 amino acid peptide produced primarily by endocrine cells of the ileal mucosa. Physiological actions of Neurotensin include hypertension, vasodilation, hyperglycemia, and inhibition of gastric motility. Its C-terminus is similar to Angiotensin I. It is a potent analgesic affecting hypothermia, muscle relaxation, and decreased motor activity. Pancreatic Polypeptide secretion is strongly stimulated by Neurotensin. Neurotensin appears to cause the release of Luteinizing Hormone-Releasing Hormone and Corticotropin Releasing Hormone effecting the release of Luteinizing Hormone, Follicle Stimulating Hormone, and ACTH but not Thyroid Stimulating Hormone or Growth Hormone. Neurotensin also stimulates pancreatic bicarbonate and intestinal secretion. Neurotensin levels are stimulated by food and Bombesin. Elevated levels have been found in pancreatic endocrine tumors, Oat Cell, Squamous, and Adeno Carcinomas.

Elevated levels have been found to cause watery diarrhea.

Reference Values

50 - 100 pg/mL

Cautions

No significant cautionary statements

Day(s) Performed

Monday through Friday

Report Available

5 - 9 days

Performing Laboratory

Inter Science Institute

Test Classification

This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.

CPT Code Information

83519

NY State Approved

No