Reference Values

COMPREHENSIVE PROFILE

TOTAL PTH Reference Range:     14.0 - 66.0 pg/mL

CAP PTH Reference Range:             5.0 - 39.0 pg/mL

CIP VALUE Reference Range:         2.5 - 29.0 pg/mL

CAP/CIP Reference Range:              1.1 - 6.9 ratio

Low ratio or PTH values are associated with Adynamic bone turnover status for an ESRD patient.

Total PTH:

Total Intact PTH is the sum of CAP PTH and N-truncated PTH fragment (likely 7-84) Total PTH = Intact PTH = CAP + CIP.

FDA approved.

CAP PTH:

CAP stands for Cyclase Activating PTH and is the same as Whole PTH which is 1-84 PTH and which raises bone turnover.

FDA approved.

CIP VALUE:

CIP stands for Cyclase Inactive PTH and the N-truncated PTH fragment, likely 7-84 PTH. CIP = Total PTH – CAP.

CAP/CIP:

CAP/CIP ratio is a calculated value and has been shown to be 93% predictive of bone turnover for the ESRD patient, however, bone biopsy is 100% predictive, therefore, clinical correlation is recommended.

Reference ranges were established using a 95% reference interval on a normal population with normal functioning kidneys. These reference ranges should not be applied to ESRD patients with impaired or non-functioning renal function.