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HelpTest ID FRDP Rickettsial Disease Panel
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FRTGM | R. Typhi IgG/IgM Reflex to Titers | No | Yes |
| FRMGM | RMSF IgG/IgM Reflex to Titers | No | Yes |
| FQGI | Q Fever IgG Phase I Screen | No | Yes |
| FQG2S | Q Fever IgG Phase II Screen | No | Yes |
| FQMI | Q Fever IgM Phase I Screen | No | Yes |
| FQM2S | Q Fever IgM Phase II Screen | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| FRTG | R. Typhi IgG Titer | No | No |
| FRTM | R. Typhi IgM Titer | No | No |
| FRMFG | RMSF IgG Titer | No | No |
| FRMFM | RMSF IgM Titer | No | No |
| FQFG1 | Q Fever IgG Phase I Titer | No | No |
| FQFG2 | Q Fever IgG Phase II Titer | No | No |
| FQFM1 | Q Fever IgM Phase I Titer | No | No |
| FQFM2 | Q Fever IgM Phase II Titer | No | No |
Testing Algorithm
If R. Typhi IgG is Detected - FRTG Rickettsia (Typhus Fever) IgG Titer will be performed at an additional charge.
If R. Typhi IgM is Detected - FRTM Rickettsia (Typhus Fever) IgM Titer will be performed at an additional charge.
If RMSF IgG is Detected - FRMFG Rickettsia (RMSF) IgG Titer will be performed at an additional charge.
If RMSF IgM is Detected - FRMFM Rickettsia (RMSF) IgM Titer will be performed at an additional charge.
If Q Fever IgG Phase I (FQGI) is Positive – FQFG1 Q Fever IgG Phase I Titer will be performed at an additional charge.
If Q Fever IgM Phase I (FQMI) is Positive – FQFG2 Q Fever IgM Phase I Titer will be performed at an additional charge.
If Q Fever IgG Phase II (FQG2S) is Positive – FQFM1 Q Fever IgG Phase II Titer will be performed at an additional charge.
If Q Fever IgM Phase II (FQM2S) is Positive – FQFM2 Q Fever IgM Phase II Titer will be performed at an additional charge.
Method Name
Immunofluorescence Assay (IFA)
Reporting Name
Rickettsial Disease PanelSpecimen Type
SerumDraw blood in a plain red-top or serum gel tube(s). Spin down and send 2 mL of serum refrigerated.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 30 days | |
| Ambient | 7 days |
Reference Values
R. Typhi IgG/IgM
RMSF IgG/IgM
Reference Range: Not Detected
Q Fever IgG/IgM Phase I/II Screens
Reference Range: Negative
Q Fever Antibody testing includes differentiation of antibodies to Phase I and Phase II antigenic variants. Coxiella burnetii, which causes Q Fever, undergoes transitions between Phase I and Phase II states. These phases are serologically distinguishable and useful in the serodiagnosis of acute and chronic disease.
In some cases, the ratio of titer of phase II to phase I may indicate the stage of the disease. A ratio of greater than 1 may indicate the acute stage; greater than or equal to 1, granulomatous hepatitis; and less than 1, the chronic stage or endocarditis.
As with other infectious diseases, IgM antibodies are the first to appear. Usually they are detectable for a few weeks or, at the most, for a few months. IgG antibodies appear somewhat later but can persist for years, even for life.
Although single phase II IgG titers of 1:256 or greater are considered evidence of acute C. burnetii disease, the best criterion for a dependable diagnosis is still the demonstration of a fourfold or higher increase in antibody titer between the acute and convalescent serum samples.
Day(s) Performed
Monday through Friday
Report Available
1 - 4 daysPerforming Laboratory
Focus Diagnositics, Inc.CPT Code Information
86638/x4 Q Fever
86757/x4 Rickettsia
86638/each Q Fever titer (if appropriate)
86757/each Rickettsia titer (if appropriate)