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HelpTest ID FSEC Secretin
Method Name
Direct Radioimmunoassay (RIA)
Reporting Name
Secretin (Plasma)Specimen Type
GI PlasmaSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| GI Plasma | Frozen | 30 days |
Clinical Information
Secretin is a 27 amino acid basic peptide produced by S cells and
released by acid delivered into the duodenum. Secretin is released
into the blood when duodenal pH drops below 4. Secretin shares
structural similarity with Glucagon, Gastric Inhibitory Polypeptide,
Vasoactive Intestinal Polypeptide, PHIM, and Growth Hormone-
Releasing Hormone. Secretin is a potent stimulus for bicarbonate
secretion. Secretin also stimulates secretion of bile, release of Insulin,
and release of Gastric Pepsin in the stomach. Secretin inhibits Glucagon
release, intestinal motility, and prevents the uptake of water and sodium
ions by the intestine. In normal patients, Secretin has little effect on Gastrin
levels, but stimulates Gastrin greatly in Zollinger-Ellison patients. Secretin
is also elevated in Zollinger-Ellison patients and in patients with duodenal
ulcer. Secretin levels are low in patients with pernicious anemia and
achlorhydria. Secretin secretion can be suppressed by Somatostatin,
Cimetidine, and Methionine-Enkephalin.
Reference Values
12 - 75 pg/mL (mean=25)
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Day(s) Performed
Monday through Friday
Report Available
7 - 10 daysPerforming Laboratory
Inter Science InstituteTest Classification
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.CPT Code Information
83519