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Test ID FSH Follicle-Stimulating Hormone (FSH), Serum

Useful For

An adjunct in the evaluation of menstrual irregularities

 

Evaluating patients with suspected hypogonadism

 

Predicting ovulation

 

Evaluating infertility

 

Diagnosing pituitary disorders

Method Name

Immunoenzymatic Assay

Reporting Name

FSH, S

Specimen Type

Serum

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.6 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

Additional Information: Twelve hours before this blood test, do not take multivitamins or dietary supplements containing biotin or vitamin B7 that are commonly found in hair, skin and nail supplements and multivitamins.

 

Forms: If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen

(http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  7 days

Clinical Information

Gonadotropin-releasing hormone from the hypothalamus controls the secretion of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.

 

The menstrual cycle is divided by a midcycle surge of both FSH and LH into a follicular phase and a luteal phase.

 

FSH appears to control gametogenesis in both males and females.

Reference Values

Males

1-7 days: ≤3.0 IU/L

8-14 days: ≤1.4 IU/L

15 days-3 years: ≤2.5 IU/L

4-6 years: ≤6.7 IU/L

7-8 years: ≤4.1 IU/L

9-10 years: ≤4.5 IU/L

11 years: 0.4-8.9 IU/L

12 years: 0.5-10.5 IU/L

13 years: 0.7-10.8 IU/L

14 years: 0.5-10.5 IU/L

15 years: 0.4-18.5 IU/L

16 years: ≤9.7 IU/L

17 years: 2.2-12.3 IU/L

≥18 years: 1.0-18.0 IU/L

 

TANNER STAGES*

Stage l: ≤3.7 IU/L

Stage ll: ≤12.2 IU/L

Stage lll: ≤17.4 IU/L

Stage lV: 0.3-8.2 IU/L

Stage V: 1.1-12.9 IU/L

*Puberty onset occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

 

Females

1-7 days: ≤3.4 IU/L

8-14 days: ≤1.0 IU/L

15 days-6 years: ≤3.3 IU/L

7-8 years: ≤11.1 IU/L

9-10 years: 0.4-6.9 IU/L

11 years: 0.4-9.0 IU/L

12 years: 1.0-17.2 IU/L

13 years: 1.8-9.9 IU/L

14-16 years: 0.9-12.4 IU/L

17 years: 1.2-9.6 IU/L

≥18 years:

Premenopausal

Follicular: 3.9-8.8 IU/L

Midcycle: 4.5-22.5 IU/L

Luteal: 1.8-5.1 IU/L

Postmenopausal: 16.7-113.6 IU/L

 

TANNER STAGES*

Stage l: 0.4-6.7 IU/L

Stage ll: 0.5-8.7 IU/L

Stage lll: 1.2-11.4 IU/L

Stage lV: 0.7-12.8 IU/L

Stage V: 1.0-11.6 IU/L

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.

 

Pediatric ranges derived for DXI method from analytic comparison to reference method in: Elmlinger MW, Kuhnel W, Ranke MB: Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults. Clin Chem Lab Med 2002;40(11):1151-1160

Cautions

Twelve hours before this blood test, do not take multivitamins or dietary supplements containing biotin or vitamin B7 that are commonly found in hair, skin and nail supplements and multivitamins.

 

No clinically significant cross-reactivity has been demonstrated with thyroid-stimulating hormone, luteinizing hormone, human chorionic gonadotropin, prolactin, or growth hormone.

 

Some patients who have been exposed to animal antigens, either in the environment or as part of treatment or imaging procedures, may have circulating antianimal antibodies present. These antibodies may interfere with the assay reagents to produce unreliable results.

Day(s) Performed

Monday through Friday; 5 a.m.-12 a.m., Saturday; 6 a.m.-6 p.m.

Report Available

Same day/1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83001

NY State Approved

Yes