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HelpTest ID FSLAA Soluble Liver Antigen (SLA) Autoantibody
Method Name
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Specimen Required
Specimen Type: Serum
Container/Tube: Red or SST
Specimen Volume: 1 mL
Collection Instructions: Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum refrigerated in a plastic vial.
Reporting Name
SLA AutoantibodySpecimen Type
SerumSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 8 days |
| Frozen | 28 days | |
| Ambient | 48 hours |
Report Available
2 to 13 daysPerforming Laboratory
Quest Diagnostics Nichols InstituteLOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| FSLAA | SLA Autoantibody | 32219-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| FSLAA | SLA Autoantibody | 32219-8 |
Day(s) Performed
Wednesday
CPT Code Information
83520
Specimen Minimum Volume
0.3 mL
Reference Values
Negative 0.0-20.0 U
Equivocal 20.1-24.9 U
Positive >25.0 U
Antibodies to soluble liver antigen (SLA) appear to be directed against the UGA-suppressor tRNA associated protein. These antibodies are highly specific for autoimmune hepatitis (AIH) and may rarely, be the only autoantibodies detected in serum from such patients. Antibodies to SLA are most closely associated with AIH type 1; the presence of these antibodies in patients with cryptogenic hepatitis suggests that these patients may have AIH type 1.
Anti-SLA antibodies may be detected in some patients with the primary biliary cirrhosis-AIH overlap syndrome, but not in healthy controls.