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Test ID FSOMA Somatostatin

Method Name

Direct Radioimmunoassay (RIA)

Reporting Name

Somatostatin (Plasma)

Specimen Type

GI Plasma

Collect 10 mL of blood in special tube containing G.I. Preservative (MML supply number T125). Specimen should be separated and 3 mL plasma frozen as soon as possible.

 

Patient preparation:

            1)  Patient should be fasting 10-12 hours prior to collection.

            2)  Patient should not be on any antacid medication or medications that affect insulin secretion or intestinal motility, if possible, for at least 48 hours prior to collection.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
GI Plasma Frozen 180 days

Clinical Information

Somatostatin is a cyclic peptide originally isolated from sheep hypothalami

and shown to inhibit the release of Growth Hormone. Somatostatin is present

primarily in three main forms: a 14 amino acid peptide, a 28 amino acid peptide

(Big Somatostatin), and a 12,000 molecular weight Pro-Somatostatin. This

assay measures only the 14 amino acid form of Somatostatin. All three forms

of Somatostatin have similar biological properties and overall potencies.

Somatostatin is a physiological regulator of islet cell and gastrointestinal functions,

and is a suppressor of many pituitary hormones including Growth Hormone, Prolactin,

and Thyrotropin (TSH). Somatostatin levels are often elevated in diabetics, but the

levels return to normal upon correction of the hormonal and metabolic deficiencies

present. In many cases of APUDomas including VIPoma, Insulinoma, Glucagonoma,

and Gastrinoma, elevated levels of Somatostatin are found. 

Reference Values

Up to 25 pg/ml

 

This test was developed and its performance characteristics

determined by Inter Science Institute. It has not been cleared or

approved by the US Food and Drug Administration. The FDA

has determined that such clearance or approval is not necessary.

 

Day(s) Performed

Monday through Friday

Report Available

5 - 7 days

Performing Laboratory

Inter Science Institute

Test Classification

This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.

CPT Code Information

84307

NY State Approved

No