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Test ID GBACC Gamma-Amino Butyric Acid Type A (GABA-A) Receptor Antibody by Cell Binding Assay, Spinal Fluid


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 1 mL


Secondary ID

620231

Useful For

Evaluating patients with suspected autoimmune encephalitis and autoimmune epilepsy

Method Name

Cell Binding Assay (CBA)

Reporting Name

GABA-A-R Ab CBA, CSF

Specimen Type

CSF

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Clinical Information

Gamma-amino butyric acid type A (GABA-A) receptor autoantibodies are highly predictive of GABA-A receptor autoimmune encephalitis. Seropositive GABA-A receptor encephalitis patients have characteristic clinical-radiologic presentations including frequent seizures and multifocal lesions in the white matter. The majority of patients are treatable with immunotherapy.

Reference Values

Negative

Cautions

Negative results do not exclude the diagnosis of autoimmune encephalitis. Only 2% of cases of autoimmune encephalitis are associated with autoantibodies against gamma-amino butyric acid type A receptor.

Day(s) Performed

Monday through Sunday

Report Available

5 to 10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255

NY State Approved

Yes