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HelpTest ID GBACS Gamma-Amino Butyric Acid Type A (GABA-A) Receptor Antibody by Cell Binding Assay, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: SST
Submission Container/Tube: Plastic vial
Specimen Volume: 0.30 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Secondary ID
620232Useful For
Evaluating patients with suspected autoimmune encephalitis and autoimmune epilepsy.
Method Name
Cell Binding Assay (CBA)
Reporting Name
GABA-A-R Ab CBA, SSpecimen Type
SerumSpecimen Minimum Volume
0.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Clinical Information
Gamma-amino butyric acid type A (GABA-A) receptor autoantibodies are highly predictive of GABA-A receptor autoimmune encephalitis. Seropositive GABA-A receptor encephalitis patients have characteristic clinical-radiologic presentations including frequent seizures and multifocal lesions in the white matter. Majority of patients are treatable with immunotherapy.
Reference Values
Negative
Cautions
Negative results do not exclude the diagnosis of autoimmune encephalitis. Only 2% of cases of autoimmune encephalitis are associated with autoantibodies against gamma-amino butyric acid type A receptor.
Day(s) Performed
Monday through Sunday
Report Available
5 to 10 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86255