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Test ID GPI Glucose Phosphate Isomerase, Erythrocytes

Useful For

A second-order test in the evaluation of individuals with chronic hemolysis

Method Name

Kinetic Spectrophotometry (KS)

Reporting Name

Glucose Phosphate Isomerase, B

Specimen Type

Whole Blood ACD-B

Container/Tube:

Preferred: Yellow top (ACD solution B)

Acceptable: EDTA

Specimen Volume: 6 mL

Collection Instructions: Do not transfer blood to other containers.

Forms: If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/benign-hematology-test-request-form.pdf)

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood ACD-B Refrigerated 20 days

Clinical Information

Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease of the newborn is a common presenting manifestation of GPI deficiency.

Reference Values

≥12 months: 39.3-57.7 U/g Hb

Reference values have not been established for patients who are <12 months of age.

Cautions

No significant cautionary statements

Day(s) Performed

Monday through Friday

Report Available

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

84087

NY State Approved

Yes