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HelpTest ID HBCRQ Hepatitis B Virus Core-Related Antigen, Quantitative, Serum
Ordering Guidance
This test should be requested only in individuals with all of the following:
-Chronic hepatitis B
-Confirmed positive hepatitis B surface (HBs) antigen
-Negative hepatitis B e antigen (HBeAg)
-Positive hepatitis B e antibody (anti-HBe)
-Undetectable or low hepatitis B viral DNA levels (eg, <500 IU/mL) in serum
Additional Testing Requirements
Testing for hepatitis B virus (HBV) DNA (HBVQN / Hepatitis B Virus [HBV] DNA Detection and Quantification by Real-Time PCR, Serum) and surface antigen (HBAGQ / Hepatitis B Virus Surface Antigen, Quantitative, Serum) levels in serum will be helpful in monitoring response to curative antiviral therapy for chronic hepatitis B.
Shipping Instructions
Ship specimen frozen on dry ice only. If shipment will be delayed for more than 24 hours, freeze serum at -20 degrees to -80° C (up to 60 days) until shipment on dry ice.
Necessary Information
Collection date is required.
Specimen Required
Collection Container/Tube: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions:
1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).
2. Transfer serum into aliquot tube.
Updated 09/19/2025
Forms
f not ordering electronically, complete, print, and send 1 of the following:
Useful For
Monitoring of response to antiviral therapy in individuals with chronic hepatitis B who are negative for hepatitis B e antigen (HBeAg), positive for hepatitis B e antibody, and undetectable or low hepatitis B virus DNA levels (eg, <500 IU/mL) in serum
Testing Algorithm
For more information see Hepatitis B: Testing Algorithm for Screening, Diagnosis, and Management
Special Instructions
Method Name
Chemiluminescent Enzyme Immunoassay
Reporting Name
HBcr Ag, Quantitative, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen (preferred) | 28 days |
| Refrigerated | 14 days | |
| Ambient | 7 days |
Reference Values
<1000 U/mL
Day(s) Performed
Every other Tuesday
Report Available
1 to 14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82397
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HBCRQ | HBcr Ag, Quantitative, S | 97152-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| HBCQ2 | HBcr Ag, Quantitative, S | 97152-3 |