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Test ID HBZ Human T-cell Lymphotropic Virus Type 1 (HTLV-1) bZIP Factor (HBZ), In Situ Hybridization, Technical Component Only


Ordering Guidance


This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required, order PATHC / Pathology Consultation.



Shipping Instructions


Attach the green pathology address label and the pink Immunostain Technical Only label included in the kit to the outside of the transport container.



Specimen Required


Supplies: Immunostain Technical Only Envelope (T693)

Specimen Type: Tissue

Container/Tube: Immunostain Technical Only Envelope

Preferred: 4 Unstained positively charged glass slide (25- x 75- x 1-mm) per test ordered; sections 4-microns thick.

Acceptable: Formalin-fixed, paraffin-embedded (FFPE) tissue block


Secondary ID

618481

Useful For

Diagnosing adult T-cell leukemia/lymphoma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ISTOI ISH Initial, Tech Only No No
ISTOA ISH Additional, Tech Only No No

Testing Algorithm

For the initial technical component only in situ hybridization (ISH) stain performed, the appropriate bill only test ID will be reflexed and charged (ISTOI). For each additional technical component only ISH stain performed, an additional bill only test ID will be reflexed and charged (ISTOA).

Method Name

In Situ Hybridization (ISH)

Reporting Name

HBZ ISH, Tech Only

Specimen Type

TECHONLY

Specimen Stability Information

Specimen Type Temperature Time
TECHONLY Ambient (preferred)
  Refrigerated 

Clinical Information

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy induced by human T-cell lymphotropic virus 1 (HTLV-1) infection. This test is intended to identify the presence of HTLV-1 in formalin-fixed, paraffin-embedded tissue, which may be useful in the diagnosis of ATLL.

Cautions

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88365-TC, Primary

88364-TC, if additional ISH

NY State Approved

Yes