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Test ID HEXU Iohexol, Timed Collection, Urine


Specimen Required


Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions: Collect a timed urine specimen.


Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.

Secondary ID

61712

Useful For

Determining glomerular filtration rate in urine specimens

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Iohexol, U

Specimen Type

Urine

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 7 days
  Frozen  35 days

Clinical Information

The assessment of glomerular filtration rate (GFR) is an important parameter of renal function utilized by clinicians in the care of patients with varying renal diseases, and for clinical research when precise assessment of renal function is necessary. The GFR is the sum of all the filtration rates of the individual nephrons within the kidney and, as such, reflects the number of functioning nephrons.

 

Urine concentrations of iohexol can be used for measurement of GFR following a subcutaneous injection of iohexol (plasma disappearance), or during a continuous infusion of iohexol when used in conjunction with plasma iohexol determinations (HEXP / Iohexol, Plasma). The results can be used to determine the clearance of iohexol, which is a measure of GFR.

Reference Values

Not applicable

Cautions

A theoretical complication to injection of iodinated contrast media (one that has not been observed clinically to date) is the transient suppression of thyroid function in premature and newborn infants. Therefore, a sensitive thyrotropin test is suggested approximately 2 to 3 weeks after an iohexol clearance in that age group.

Day(s) Performed

Monday through Friday

Report Available

3 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

NY State Approved

Yes