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HelpTest ID HOLDC Hematologic Disorders, Chromosome Hold, Bone Marrow or Peripheral Blood
Useful For
Holding the bone marrow or peripheral blood specimen in the laboratory but delaying chromosome analysis while preliminary morphologic assessment is in process
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| CHRBM | Chromosomes, Hematologic, BM | Yes | No |
| CHRHB | Chromosomes, Hematologic, Blood | Yes | No |
Testing Algorithm
This test is designed to hold the specimen but delay chromosome preparation and analysis while preliminary morphologic assessment is in process.
Upon specimen receipt, the specimen will be held in the laboratory. Chromosome analysis will be performed unless the test is canceled (see HOLD policy).
If the client notifies the laboratory that chromosome analysis is not necessary, this test will be reported as "canceled." Chromosome analysis will not be performed but a processing fee will be charged.
If the client does not notify the laboratory that chromosome analysis is not needed (see HOLD policy), this test will be reported as "reflexed" and chromosome analysis will be performed. Depending on the specimen received, the appropriate reflex test will be performed. No processing fee will be assessed for this test as culture charges are included in the reflexed test.
HOLD policy: The client must contact the Cytogenetics Laboratory at 507-266-0790 by 4 p.m. (central time) no later than 2 business days after the specimen was collected to notify the lab not to proceed with chromosome analysis. If no notification is received by this time, chromosome analysis will be performed and charged. Weekend communication can be deferred until Monday.
Method Name
Direct Preparation of Specimen
Reporting Name
Heme Chromosome Hold, B/BMSpecimen Type
VariesProvide a reason for referral with each specimen and bone marrow pathology report (if available). The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
Advise Express Mail or equivalent if not sent via courier service.
Forms: If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request Form (T726) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/hematopathology-request-form.pdf)
Submit only 1 of the following specimens:
Specimen Type: Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 7-10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Type: Bone marrow
Container/Tube: Green top (sodium heparin)
Specimen Volume: 2-3 mL
Collection Instructions:
1. It is preferable to send the first aspirate from the bone marrow collection.
2. Invert several times to mix bone marrow.
3. Other anticoagulants are not recommended and are harmful to the viability of the cells.
Specimen Minimum Volume
Blood: 2 mL/Bone Marrow: 1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Varies | Ambient (preferred) | |
| Refrigerated | ||
Clinical Information
Conventional chromosome analysis is the gold standard for identification of the common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, chromosome analysis may not be necessary. Depending on the diagnosis, FISH assays may also be more informative.
Reference Values
Not applicable
Cautions
This test does not apply to any FISH assays. If specimen is to be held for FISH testing, HOLDF / Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Bone Marrow or Peripheral Blood must be ordered.
Day(s) Performed
Samples processed Monday through Sunday. Results reported Monday through Friday, 8 a.m.-5 p.m. CST.
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
CPT Code Information
See individual reflex tests