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HelpTest ID IBDP Inflammatory Bowel Disease Serology Panel, Serum
Useful For
As an adjunct in the diagnosis of ulcerative colitis and Crohns disease in patients suspected of having inflammatory bowel disease
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| AASCA | Saccharomyces cerevisiae Ab, IgA, S | Yes | Yes |
| GASCA | Saccharomyces cerevisiae Ab, IgG, S | Yes | Yes |
| NSA | Neutrophil Specific Antibodies | No | Yes |
Method Name
AASCA, GASCA: Enzyme-Linked Immunosorbent Assay (ELISA)
NSA: Indirect Immunofluorescent Assay (IFA)
Reporting Name
Inflammatory Bowel Disease Panel, SSpecimen Type
SerumContainer/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 0.5 mL
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Clinical Information
The term "inflammatory bowel disease" (IBD) is often used to refer to 2 diseases, ulcerative colitis (UC) and Crohn's disease (CD), that produce inflammation of the large or small intestines. The diagnosis of these 2 diseases is based on clinical features, the results of barium X-rays, colonoscopy, mucosal biopsy histology, and in some cases operative findings and resected bowel pathology and histology.
Recently, patients with IBD have been shown to have antibodies in serum that help to distinguish between CD and UC.(1) Patients with UC often have measurable neutrophil specific antibodies (NSA), which react with as yet uncharacterized target antigens in human neutrophils; whereas, patients with CD often have measurable antibodies of the IgA and/or IgG isotypes, which react with cell wall mannan of Saccharomyces cerevisiae strain Su 1.
Reference Values
Saccharomyces cerevisiae ANTIBODY, IgA
Negative: ≤20.0 U
Equivocal: 20.1-24.9 U
Weakly positive: 25.0-34.9 U
Positive: ≥35.0 U
Saccharomyces cerevisiae ANTIBODY, IgG
Negative: ≤20.0 U
Equivocal: 20.1-24.9 U
Weakly positive: 25.0-34.9 U
Positive: ≥35.0 U
NEUTROPHIL-SPECIFIC ANTIBODIES
Negative (not detectable)
Cautions
Results from this test should not be exclusively relied upon to establish the diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) or to distinguish between these 2 diseases. Some patients with CD have detectable neutrophil specific antibodies (NSA), and some patients with UC have elevated levels of IgA and/or IgG anti-Saccharomyces cerevisiae antibodies (ASCA).
Approximately one third of patients have low titered anti-nuclear antibodies (ANA), which make it impossible to distinguish the presence or absence of NSA. These results are reported as indeterminate.
Not useful to determine the extent of disease in patients with inflammatory bowel disease (IBD) or determine the response to disease-specific therapy including surgical resection of diseased intestine.
Day(s) Performed
Varies
Report Available
Same day/1 dayPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions.CPT Code Information
86255
86671 x 2