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HelpTest ID LSDU Lysergic Acid Diethylamide (LSD) Confirmation, Urine
Useful For
Confirming use of lysergic acid diethylamide
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Confirmation with Quantitation
Reporting Name
LSD Confirmation, USpecimen Type
UrineContainer/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 20 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
Additional Information:
1. No specimen substitutions.
2. No STATS are accepted for this procedure.
3. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order LSDX / Lysergic Acid Diethylamide (LSD) Confirmation, Chain of Custody, Urine.
4. Additional drug panels and specific requests are available. Call Mayo Medical Laboratories at 800-533-1710 or 507-266-5700.
5. If urine creatinine is required or adulteration of the sample is suspected, the following test should be requested, ADULT / Adulterants Survey, Urine. For additional information, please refer to ADULT / Adulterants Survey, Urine.
6. Submitting less than 20 mL will compromise our ability to perform all necessary testing.
Forms: Chain-of-Custody Request Form is included in the Chain-of-Custody Kit (T282). A copy of this form is also available at http://www.mayomedicallaboratories.com/it-mmfiles/chain-of-custody-request-form.pdf.
Specimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 72 hours |
Clinical Information
Lysergic acid diethylamide (LSD) is an extremely potent psychedelic ergot alkaloid derived from the fungus, Claviceps purpurea.(1) The drug LSD binds to serotonin receptors in the central nervous system and acts as a serotonin agonist.
The clearance half-life of LSD averages 3 to 4 hours. It takes 5 to 7 half-lives to clear 98% of a drug dose. Therefore, the presence of LSD greater than the lower limit of quantification (LOQ; cutoff concentration) indicates exposure to LSD within 1 day.(2)
LSD is metabolized to 2-oxo-3-hydroxy-LSD, which is present at concentrations 16 to 43 times higher than LSD, and is likely to be present in urine for up to 4 days after last exposure.(3,4)
Reference Values
Negative
Cutoff concentrations:
LSD BY LC-MS/MS
<0.5 ng/mL
2-OXO-3-HYDROXY-LSD BY LC-MS/MS
<5.0 ng/mL
Cautions
The liquid chromatography-tandem mass spectrometry test is not subject to any known interference.
Day(s) Performed
Wednesday
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
80323
G0480 (if appropriate)