Sign in →

Test ID LY27B HLA-B27, Blood


Ordering Guidance


This test is best used alone if a particular disease, such as ankylosing spondylitis, is under consideration.

 

Orders received for both this test and 1LRR / Human Leukocyte Antigens (HLA) Class I Typing Low Resolution, Recipient, Blood or 1DIS / Human Leukocyte Antigens (HLA) A-B-C Disease Association Typing Low Resolution, Blood (which provides data on all HLA Class I low-resolution antigens, including B27) will be questioned due to test overlap.



Shipping Instructions


Specimen must arrive within 96 hours of collection.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Forms

If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.

Secondary ID

9648

Useful For

Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome

Method Name

Flow Cytometry

Reporting Name

HLA-B27, B

Specimen Type

Whole Blood EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Ambient 4 days

Clinical Information

This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.

 

There is an increased prevalence of human leukocyte antigen (HLA)-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.

 

Studies have demonstrated that the B*27:06 allele, which is present in a small percentage of individuals of Asian ethnicity, may not be associated with ankylosing spondylitis.

Reference Values

An interpretive report will be provided.

Cautions

Extreme temperature changes during shipping may alter the specimen making it unacceptable for testing.

Day(s) Performed

Monday through Saturday

Report Available

2 to 6 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86812

NY State Approved

Yes