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HelpTest ID LY27B HLA-B27, Blood
Useful For
Assisting in the diagnostic process of ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome
Method Name
Flow Cytometry
Reporting Name
HLA-B27, BSpecimen Type
Whole Blood EDTASpecimen must arrive within 96 hours of draw.
Container/Tube: Lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Do not transfer blood to other containers.
Forms: If not ordering electronically, complete, print, and send a General Test Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf).
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood EDTA | Ambient | 4 days |
Clinical Information
This major histocompatibility coded class I antigen is associated with ankylosing spondylitis, juvenile rheumatoid arthritis, and Reiter syndrome. The mechanism of the association is not understood but probably is that of linkage disequilibrium.
There is an increased prevalence of HLA-B27 in certain rheumatic diseases, particularly ankylosing spondylitis.
Studies have demonstrated that the B*27:06 allele, which is present in a small percentage of individuals of Asian ethnicity, may not be associated with ankylosing spondylitis.
Reference Values
An interpretive report will be provided.
Cautions
Orders received for both this test and SSO1 / HLA Class I Molecular Phenotype, Blood or DISI / HLA Class I Molecular Typing Disease Association (which provides data on all HLA Class I low-resolution antigens, including B27) will be questioned due to test overlap. This HLA-B27 test is best used alone if a particular disease such as ankylosing spondylitis is under consideration.
Extreme temperature changes during shipping may alter the specimen making it unacceptable for testing.
Day(s) Performed
Monday through Friday; 7:30-5 p.m.
Saturday; 10 a.m.-6 p.m.
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86812