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Test ID MALD M-Protein Isotype, Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry, Serum


Specimen Required


Patient Preparation: Fasting 12 hours preferred but not required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container /Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot into a plastic vial.


Secondary ID

609780

Useful For

Aiding in the diagnosis of monoclonal gammopathies, when used in conjunction with free light chain studies

 

This test alone is not considered an adequate screen for monoclonal gammopathies.

Profile Information

Test ID Reporting Name Available Separately Always Performed
MALDO M-Protein Isotype Only, S No Yes
TMAB Therapeutic Antibody Administered? No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IFXED Immunofixation Delta and Epsilon, S Yes No

Testing Algorithm

This test includes M-protein isotyping. If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.

Method Name

MALDO: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS)

TMAB: Patient Information

Reporting Name

M-Protein Isotype Only, S

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Clinical Information

Immunotyping of monoclonal (M-) proteins identifies the monoclonal immunoglobulin heavy chain type (gamma, alpha, mu, delta, or epsilon) and light chain type (kappa or lambda) in serum specimens.

Reference Values

Negative: No monoclonal protein detected.

Cautions

No significant cautionary statements

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

0077U

86334 (if appropriate)

NY State Approved

Yes