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Test ID MYGLS Myoglobin, Serum


Specimen Required


Collection Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Secondary ID

606735

Useful For

Assessing muscle damage from any cause

Method Name

Latex Particle-Enhanced Immunoturbidometric Assay

Reporting Name

Myoglobin, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Clinical Information

Myoglobin is a heme protein found in smooth and skeletal muscles. Serum myoglobin reflects a balance between intravascular release of myoglobin from muscle and renal clearance.

 

Previously serum myoglobin had been advocated as a sensitive marker for early acute myocardial injury (eg, acute myocardial infarction: AMI). However, more recent studies indicate that other newer markers (eg, troponin) provide superior diagnostic utility in detecting early myocardial injury.

 

Elevation of serum myoglobin may occur as a result of muscle trauma, resuscitation, myopathies, AMI, shock, strenuous body activity, or decreased elimination during renal insufficiency. Extreme elevations occur in rhabdomyolysis.

Reference Values

≤90 mcg/L

Cautions

Elevation is nonspecific for acute myocardial infarction. The test is of no value in this regard in the presence of renal failure, rhabdomyolysis, extensive trauma, acute peripheral vascular occlusion, or after seizures.

 

Serum levels rise in renal insufficiency.

 

In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.

 

Results are unreliable in lipemic serum; specimens that cannot be cleared by ultracentrifugation will be rejected.

Day(s) Performed

Monday through Sunday

Report Available

1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83874

NY State Approved

Yes