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HelpTest ID MYGLU Myoglobin, Urine
Useful For
Confirming the presence of a myopathy associated with any 1 of the disorders listed in Clinical Information
May suggest a myopathic cause for acute renal failure
Method Name
Latex Particle-Enhanced Immunoturbidometric Assay
Reporting Name
Myoglobin, USpecimen Type
UrineContainer/Tube: Plastic, 10-mL urine myoglobin transport tube (Supply T691)
Specimen Volume: 5 mL
Collection Instructions:
1. Collect a preservative-free, random urine specimen.
2. If specimen is at ambient temperature, aliquot the urine to a urine myoglobin transport tube (Supply T691) within 1 hour of collection. Refrigerate specimen.
3. If specimen is refrigerate, aliquot the urine to a urine myoglobin transport tube (Supply T691) within 2 hours of collection.
Additional Information: Urinary myoglobin is highly unstable unless alkalinized with Na2CO3 preservative. Even with alkalinization, myoglobin deterioration is variable and specimen dependent (approximate averages of 10% at 1 day, 20% at 3 days, and 30% at 7 days).
Specimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated | 7 days |
Clinical Information
Myoglobin is the oxygen-binding protein of striated muscle. Injury to skeletal or cardiac muscle results in the release of myoglobin. High concentrations appear very rapidly in the urine in various conditions including some metabolic diseases.
Conditions associated with myoglobinuria include:
-Hereditary myoglobinuria
-Phosphorylase deficiency
-Sporadic myoglobinuria
-Exertional myoglobinuria in untrained individuals
-Crush syndrome
-Myocardial infarction
-Myoglobinuria of progressive muscle disease
-Heat injury
Urine myoglobin increases with muscle necrosis, but the clinical consequences are variable. Therefore, myoglobin can confirm a clinical diagnosis of myopathy, but an elevated urine excretion of myoglobin is not specific for a clinical disorder.
In acute renal failure, an elevated urinary myoglobin can suggest a potential cause and, consequently, may indicate appropriate treatment courses.
Reference Values
≤21 mcg/L
Cautions
An elevated level of myoglobin in urine does not identify the clinical disorder.
Urine collected with acid as preservative will not be valid because acid interferes with analyte integrity.
Urinary myoglobin deteriorates rapidly unless stabilized immediately after collection by alkalizing with Na2CO3.
Urinary myoglobin does not withstand freezing even when pH is raised with Na2CO3.
Day(s) Performed
Monday through Sunday, continuous
Report Available
1 dayPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
83874