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HelpTest ID NEEVP Neurologic Enzyme Evaluation
Useful For
Evaluating patients who have a hemolytic process that is associated with some neurologic findings
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| NEEV | Neurologic Enzyme Interpretation | No | Yes |
| GLTI | Glutathione, B | No | Yes |
| PFK | Phosphofructokinase, RBC | No | Yes |
| PGK | Phosphoglycerate Kinase, B | No | Yes |
| TPI | Triosephosphate Isomerase, B | No | Yes |
| P5NT | Pyrimidine 5' Nucleotidase, B | Yes | Yes |
Method Name
NEEV: Consultative Interpretation
GLTI, PFK, PGK, TPI, P5NT: Kinetic Spectrophotometry (KS)
Reporting Name
Neurologic Enzyme EvaluationSpecimen Type
Whole Blood ACD-BContainer/Tube: Yellow top (ACD)
Specimen Volume: 10 mL
Collection Instructions: Do not transfer blood to other containers.
Forms: If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/benign-hematology-test-request-form.pdf)
Specimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Whole Blood ACD-B | Refrigerated | 8 days |
Clinical Information
Several RBC enzymes are known to cause a nonspherocytic hemolytic anemia (HA). The most common cause of these are glucose-6-phosphate dehydrogenase and pyruvate kinase deficiency. Four other RBC enzymes that cause HA have also been associated with hereditary myopathic or neurologic disorders. These enzymes are phosphofructokinase, triosephosphate isomerase, phosphoglycerate kinase, and glutathione synthase. Kinetic enzyme assays are available for the first 3 disorders. Quantitative measurement of glutathione substitutes for analysis of the enzyme glutathione synthase.
Reference Values
Definitive results and an interpretive report will be provided.
Cautions
No significant cautionary statements
Day(s) Performed
Monday through Friday; Varies
Report Available
10 days (not reported Saturday or Sunday)Performing Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
82657-RBC enzymes
82978-Glutathione
83915-Pyrimidine 5’ Nucleotidase