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HelpTest ID NMH1D N-Methylhistamine, 24 Hour, Urine
Ordering Guidance
Random urine collection is preferred for patients with episodic symptoms, eg, in the context of allergic reactions, brought on by specific environmental factors; order NMHR / N-Methylhistamine, Random, Urine.
Specimen Required
Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.
Patient Preparation: Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Plastic, 5-mL tube
Specimen Volume: 5 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. No preservative.
3. Aliquot into plastic tube and send at refrigerate temperature.
Reporting Name
N-Methylhistamine, 24 Hr, USpecimen Type
UrineSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 28 days |
| Ambient | 28 days | |
| Frozen | 28 days |
Report Available
3 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| NMH1D | N-Methylhistamine, 24 Hr, U | 44340-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 605159 | N-Methylhistamine, 24 Hr | 44340-8 |
Useful For
Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions as a part of a profile
Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis
Day(s) Performed
Monday, Wednesday, Friday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
Specimen Minimum Volume
3 mL
Reference Values
Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.
0-5 years: 120-510 mcg/g creatinine
6-16 years: 70-330 mcg/g creatinine
>16 years: 30-200 mcg/g creatinine
Method Name
Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)