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Test ID NSAIP Neurosyphilis IgG Antibody Index with VDRL, Serum and Spinal Fluid

Profile Information

Test ID Reporting Name Available Separately Always Performed
NSCSF Neurosyphilis IgG Screen, CSF No Yes
NSSER Neurosyphilis IgG, S No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
NSAI Neurosyphilis IgG, Ab Index No No
VDSFT VDRL Titer,CSF No No

Testing Algorithm

Testing begins with syphilis IgG screening of the spinal fluid (CSF) specimen. If the screen is negative, no additional testing will be performed.

 

If the CSF screen is reactive, the paired CSF and serum specimens will be used to establish the antibody index. To do this, the paired serum and CSF samples (collected within 24 hours of each other) are tested on the same run using quantitative assays to determine levels for the following analytes:

1. Anti-Treponema pallidum IgG in CSF and serum

2. Total IgG in CSF and serum

3. Albumin in CSF and serum

 

These additional tests are necessary to normalize the level of anti-T pallidum antibodies to total IgG and albumin in the CSF and establish the antibody index ratio of anti-T pallidum antibodies in CSF-to-serum. This testing is performed at an additional charge.

 

Samples that result as Syphilis Antibody Index negative do not undergo additional testing.

 

Samples that result as Syphilis Antibody Index positive or equivocal will be reflexed for VDRL testing to establish a semi-quantitative titer.

Reporting Name

Neurosyphilis IgG Ab Indx w/VDRL

Specimen Type

CSF
Serum

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 10 days
  Frozen  10 days
Serum Refrigerated (preferred) 10 days
  Frozen  10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NSAIP Neurosyphilis IgG Ab Indx w/VDRL In Process

 

Result ID Test Result Name Result LOINC Value
NSY1 Neurosyphilis IgG, CSF In Process
NSSER Neurosyphilis IgG, S In Process
NSY2 Neurosyphilis IgG Interp In Process