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HelpTest ID OH21 21-Hydroxylase Antibodies, Serum
Useful For
Investigation of adrenal insufficiency
Aid in the detection of those at risk of developing autoimmune adrenal failure in the future
Method Name
Immunoabsorption Assay
Reporting Name
21-Hydroxylase Ab, SSpecimen Type
SerumCollection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Specimen Minimum Volume
0.19 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Frozen (preferred) | 14 days |
| Refrigerated | 7 days |
Clinical Information
Chronic primary adrenal insufficiency (Addison disease) is most commonly caused by the insidious autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases, that together comprise Type I or Type II autoimmune polyglandular syndrome (APS).
The microsomal autoantigen 21-hydroxylase (55 kilodalton) has been shown to be the primary autoantigen associated with autoimmune Addison disease. 21-Hydroxylase antibodies are markers of autoimmune Addison disease, whether it presents alone, or as part of Type I or Type II (APS).
Reference Values
<1 U/mL
Reference values apply to all ages.
Cautions
Lipemic or grossly hemolyzed serum should not be used in this assay. Interpretation of test results requires consideration of other factors such as the clinical status of the patient, other test results, etc.
Day(s) Performed
Monday, Thursday; 2 p.m.
Report Available
2 daysPerforming Laboratory
Mayo Medical Laboratories in Rochester
Test Classification
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83519