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Test ID PBU Lead, 24 Hour, Urine

Useful For

Detecting clinically significant lead exposure

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Lead, 24 Hr, U

Specimen Type

Urine

Collection Container/Tube: Clean, plastic urine container with no metal cap or glued insert

Submission Container/Tube: Plastic, 10-mL urine tube (Supply T068) or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information:

1. 24-Hour volume is required.

2. See Urine Preservatives in Special Instructions for multiple collections.

3. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

 

Urine Preservative Collection Options

Ambient

Yes

Refrigerated

Preferred

Frozen

Yes

6N HCl

Yes

50% Acetic Acid

Yes

Na2CO3

No

Toluene

Yes

6N HNO3

Yes

Boric Acid

No

Thymol

No

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Clinical Information

Increased urine lead excretion rate indicates significant lead exposure. Measurement of urine lead excretion rate before AND after chelation therapy has been used as an indicator of lead exposure. An increase in lead excretion rate in the post chelation specimen of up to 6 times the rate in the prechelation specimen is normal. Blood lead is the best clinical correlate of toxicity.

 

For additional information, see PBBD / Lead with Demographics, Blood.

Reference Values

0-4 mcg/specimen

Reference values apply to all ages.

Cautions

This test is not a substitute for blood lead screening.

 

High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Day(s) Performed

Monday through Friday; 3 p.m.-9 p.m.; Saturday; 8 a.m.-3 p.m.; Continuously

Report Available

1 day

Performing Laboratory

Mayo Medical Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

83655

NY State Approved

Yes