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Test ID PNTO Streptococcus pneumoniae IgG Antibodies, Total, Serum

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)


Ordering Guidance


This test is the preferred test for patients previously tested for Streptococcus pneumoniae antibodies (as part of follow up testing or part of pre/post vaccine assessment).

 

The preferred test for patients being evaluated for possible immunodeficiency or for assessment of pneumococcal vaccination response (initial evaluation) is PNTOR / Streptococcus pneumoniae IgG Antibodies, Total, with Reflex, Serum.

 

The preferred test for patients previously tested for S pneumoniae serotypes (as part of follow up testing or part of pre/post vaccine assessment) is PN23M / Streptococcus pneumoniae IgG Antibodies, 23 Serotypes, Serum.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Reporting Name

S. pneumoniae IgG Ab, Total, S

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PNTO S. pneumoniae IgG Ab, Total, S 43236-9

 

Result ID Test Result Name Result LOINC Value
PNTO S. pneumoniae IgG Ab, Total, S 43236-9

Useful For

Assessing the IgG antibody response to active immunization with nonconjugated 23-valent pneumococcal vaccines

 

Assessing the IgG antibody response to active immunization with conjugated 13-valent, 15-valent and 20-valent pneumococcal vaccines

 

Determining the ability of an individual to produce an antibody response to polysaccharide antigens as part of an evaluation for humoral or combined immunodeficiencies, primarily in patients previously tested for Streptococcus pneumoniae antibodies

Day(s) Performed

Tuesday, Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86317

Specimen Minimum Volume

Serum: 0.3 mL

Reference Values

≥9.7 mcg/mL