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HelpTest ID PTU Protein, Total, 24 Hour, Urine
Necessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Collection Container/Tube: 24-hour graduated urine container with no metal cap or glued insert
Submission Container/Tube: Plastic, 5 mL tube or a clean, plastic aliquot container with no metal cap or glued insert
Specimen Volume: 4 mL
Collection Instructions:
1. Collect urine for 24 hours. Specimens should be collected before fluorescein is given or not collected until at least 24 hour later.
2. No preservative.
3. Invert well before taking 4-mL aliquot.
4. Do not over fill aliquot tube 4 mL at most.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.
Secondary ID
614001Useful For
Evaluation of kidney disease using a 24-hour urine collection
Screening for monoclonal gammopathy
Special Instructions
Method Name
Turbidimetry
Reporting Name
Protein, Total, 24 HR, USpecimen Type
UrineSpecimen Minimum Volume
1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Frozen | 30 days | |
| Ambient | 24 hours |
Clinical Information
Protein in urine is normally composed of a combination of plasma-derived proteins that have been filtered by glomeruli and have not been reabsorbed by the proximal tubules and proteins secreted by renal tubules or other accessory glands.
Increased amounts of protein in the urine may be due to:
-Glomerular proteinuria: caused by defects in permselectivity of the glomerular filtration barrier to plasma proteins (eg, glomerulonephritis or nephrotic syndrome)
-Tubular proteinuria: caused by incomplete tubular reabsorption of proteins (eg, interstitial nephritis)
-Overflow proteinuria: caused by increased plasma concentration of proteins (eg, multiple myeloma, myoglobinuria)
-Urinary tract inflammation or tumor
Reference Values
≥18 years: <229 mg/24 hours
Reference values have not been established for patients <18 years of age.
Reference value applies to 24-hour collection.
Cautions
False proteinuria may be due to contamination of urine with menstrual blood, prostatic secretions, or semen.
After vigorous exercise, the urinary protein concentration may rise to 300 mg/24 hours in healthy individuals.
Normal newborn infants may have higher excretion of protein in urine during the first 3 days of life. The presence of hemoglobin elevates protein concentration.
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 dayPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
84156