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Test ID RPTU1 Protein/Creatinine Ratio, Random, Urine


Specimen Required


Patient Preparation: Specimens should be collected before fluorescein is given or not collected until at least 24 hour later.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube: Plastic vial

Specimen Volume: 4 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

3. Invert well before taking 4 mL aliquot.

4. Do not over fill aliquot tube, 4 mL at most.


Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.

Secondary ID

614004

Useful For

Evaluation of renal disease

 

Screening for monoclonal gammopathy

Profile Information

Test ID Reporting Name Available Separately Always Performed
PTCON Protein, Total, Random, U No Yes
RATO3 Protein/Creatinine Ratio No Yes
CRETR Creatinine, Random, U No Yes

Method Name

PTCON: Turbidimetry

CRETR: Enzymatic Colorimetric Assay

RATO3: Calculation

Reporting Name

Protein/Creatinine Ratio, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  24 hours

Clinical Information

Protein in urine is normally composed of a combination of plasma-derived proteins that have been filtered by glomeruli and have not been reabsorbed by the proximal tubules and proteins secreted by renal tubules or other accessory glands.

 

Increased amounts of protein in the urine may be due to:

-Glomerular proteinuria: Caused by defects in permselectivity of the glomerular filtration barrier to plasma proteins (eg, glomerulonephritis or nephrotic syndrome)

-Tubular proteinuria: Caused by incomplete tubular reabsorption of proteins (eg, interstitial nephritis)

-Overflow proteinuria: Caused by increased plasma concentration of proteins (eg, multiple myeloma, myoglobinuria)

Reference Values

≥18 years: <0.18 mg/mg creatinine

Reference values have not been established for patients younger than 18 years of age.

Cautions

False proteinuria may be due to contamination of urine with menstrual blood, prostatic secretions, or semen.

 

Normal newborn infants may have higher excretion of protein in urine during the first 3 days of life.

 

The presence of hemoglobin elevates protein concentration.

 

Protein electrophoresis and immunofixation may be required to characterize and interpret the proteinuria.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84156

82570

NY State Approved

Yes